node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GK0078 | GK0586 | GK0078 | GK0586 | ATP-dependent Clp protease ATPase subunit; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.719 |
GK0078 | dnaJ | GK0078 | GK2503 | ATP-dependent Clp protease ATPase subunit; Belongs to the ClpA/ClpB family. | Chaperone protein (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions [...] | 0.735 |
GK0078 | dnaK | GK0078 | GK2504 | ATP-dependent Clp protease ATPase subunit; Belongs to the ClpA/ClpB family. | Chaperone protein (heat shock protein 70) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.957 |
GK0078 | groL | GK0078 | GK0249 | ATP-dependent Clp protease ATPase subunit; Belongs to the ClpA/ClpB family. | Chaperonin (GroEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.644 |
GK0078 | groS | GK0078 | GK0248 | ATP-dependent Clp protease ATPase subunit; Belongs to the ClpA/ClpB family. | Chaperonin (GroES protein); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.679 |
GK0078 | grpE | GK0078 | GK2505 | ATP-dependent Clp protease ATPase subunit; Belongs to the ClpA/ClpB family. | Chaperone protein (heat shock protein) (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the react [...] | 0.798 |
GK0078 | hrcA | GK0078 | GK2506 | ATP-dependent Clp protease ATPase subunit; Belongs to the ClpA/ClpB family. | Transcriptional repressor of class I heat shock genes; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.591 |
GK0586 | GK0078 | GK0586 | GK0078 | Hypothetical protein. | ATP-dependent Clp protease ATPase subunit; Belongs to the ClpA/ClpB family. | 0.719 |
GK0586 | GK0968 | GK0586 | GK0968 | Hypothetical protein. | ATP-dependent Clp protease; Belongs to the ClpA/ClpB family. | 0.719 |
GK0586 | clpB | GK0586 | GK0799 | Hypothetical protein. | ATP-dependent Clp protease ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.719 |
GK0586 | dnaK | GK0586 | GK2504 | Hypothetical protein. | Chaperone protein (heat shock protein 70) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.984 |
GK0586 | groL | GK0586 | GK0249 | Hypothetical protein. | Chaperonin (GroEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.823 |
GK0586 | groS | GK0586 | GK0248 | Hypothetical protein. | Chaperonin (GroES protein); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.689 |
GK0586 | grpE | GK0586 | GK2505 | Hypothetical protein. | Chaperone protein (heat shock protein) (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the react [...] | 0.905 |
GK0586 | hrcA | GK0586 | GK2506 | Hypothetical protein. | Transcriptional repressor of class I heat shock genes; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.772 |
GK0968 | GK0586 | GK0968 | GK0586 | ATP-dependent Clp protease; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.719 |
GK0968 | dnaJ | GK0968 | GK2503 | ATP-dependent Clp protease; Belongs to the ClpA/ClpB family. | Chaperone protein (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions [...] | 0.735 |
GK0968 | dnaK | GK0968 | GK2504 | ATP-dependent Clp protease; Belongs to the ClpA/ClpB family. | Chaperone protein (heat shock protein 70) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.957 |
GK0968 | groL | GK0968 | GK0249 | ATP-dependent Clp protease; Belongs to the ClpA/ClpB family. | Chaperonin (GroEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.644 |
GK0968 | groS | GK0968 | GK0248 | ATP-dependent Clp protease; Belongs to the ClpA/ClpB family. | Chaperonin (GroES protein); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.679 |