node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GK2248 | GK2262 | GK2248 | GK2262 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Threonine-phosphate decarboxylase; Histidinol-phosphate aminotransferase 1 (imidazole acetol-phosphate transaminase 1) (cobalamin biosynthesis). | 0.611 |
GK2248 | GK2799 | GK2248 | GK2799 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | 0.947 |
GK2248 | hisB | GK2248 | GK3074 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazole glycerol-phosphate dehydratase. | 0.733 |
GK2248 | hisC | GK2248 | GK2198 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol-phosphate aminotransferase (imidazole acetol-phosphate transaminase); tyrosine/phenylalanine aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.912 |
GK2248 | hisD | GK2248 | GK3075 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.940 |
GK2248 | hisH | GK2248 | GK3073 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazole glycerol phosphate synthasesubunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.559 |
GK2248 | hisI | GK2248 | GK3070 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | phosphoribosyl-AMP cyclohydrolase;phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.717 |
GK2262 | GK2248 | GK2262 | GK2248 | Threonine-phosphate decarboxylase; Histidinol-phosphate aminotransferase 1 (imidazole acetol-phosphate transaminase 1) (cobalamin biosynthesis). | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | 0.611 |
GK2262 | GK2799 | GK2262 | GK2799 | Threonine-phosphate decarboxylase; Histidinol-phosphate aminotransferase 1 (imidazole acetol-phosphate transaminase 1) (cobalamin biosynthesis). | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | 0.622 |
GK2262 | hisB | GK2262 | GK3074 | Threonine-phosphate decarboxylase; Histidinol-phosphate aminotransferase 1 (imidazole acetol-phosphate transaminase 1) (cobalamin biosynthesis). | Imidazole glycerol-phosphate dehydratase. | 0.956 |
GK2262 | hisD | GK2262 | GK3075 | Threonine-phosphate decarboxylase; Histidinol-phosphate aminotransferase 1 (imidazole acetol-phosphate transaminase 1) (cobalamin biosynthesis). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.907 |
GK2262 | hisG | GK2262 | GK3076 | Threonine-phosphate decarboxylase; Histidinol-phosphate aminotransferase 1 (imidazole acetol-phosphate transaminase 1) (cobalamin biosynthesis). | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.854 |
GK2262 | hisH | GK2262 | GK3073 | Threonine-phosphate decarboxylase; Histidinol-phosphate aminotransferase 1 (imidazole acetol-phosphate transaminase 1) (cobalamin biosynthesis). | Imidazole glycerol phosphate synthasesubunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.877 |
GK2262 | hisI | GK2262 | GK3070 | Threonine-phosphate decarboxylase; Histidinol-phosphate aminotransferase 1 (imidazole acetol-phosphate transaminase 1) (cobalamin biosynthesis). | phosphoribosyl-AMP cyclohydrolase;phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.984 |
GK2799 | GK2248 | GK2799 | GK2248 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | 0.947 |
GK2799 | GK2262 | GK2799 | GK2262 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Threonine-phosphate decarboxylase; Histidinol-phosphate aminotransferase 1 (imidazole acetol-phosphate transaminase 1) (cobalamin biosynthesis). | 0.622 |
GK2799 | GK2800 | GK2799 | GK2800 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Hypothetical conserved protein. | 0.603 |
GK2799 | ezrA | GK2799 | GK2798 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Septation ring formation regulator; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. | 0.556 |
GK2799 | hisB | GK2799 | GK3074 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazole glycerol-phosphate dehydratase. | 0.549 |
GK2799 | hisC | GK2799 | GK2198 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol-phosphate aminotransferase (imidazole acetol-phosphate transaminase); tyrosine/phenylalanine aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.954 |