node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GK0911 | guaA | GK0911 | GK0254 | Ribonucleoside-diphosphate reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | GMP synthetase (glutamine amidotransferase); Catalyzes the synthesis of GMP from XMP. | 0.635 |
GK0911 | lipA | GK0911 | GK2974 | Ribonucleoside-diphosphate reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Lipoic acid synthetase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.562 |
GK1024 | GK2379 | GK1024 | GK2379 | 2-oxoglutarate dehydrogenase complex E2 component (dihydrolipoamide transsuccinylase); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | 0.996 |
GK1024 | gcvH | GK1024 | GK3004 | 2-oxoglutarate dehydrogenase complex E2 component (dihydrolipoamide transsuccinylase); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Protein H involved in glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.583 |
GK1024 | lipA | GK1024 | GK2974 | 2-oxoglutarate dehydrogenase complex E2 component (dihydrolipoamide transsuccinylase); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Lipoic acid synthetase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.616 |
GK1024 | lipL | GK1024 | GK3414 | 2-oxoglutarate dehydrogenase complex E2 component (dihydrolipoamide transsuccinylase); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Hypothetical conserved protein; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.593 |
GK1024 | lipM | GK1024 | GK2420 | 2-oxoglutarate dehydrogenase complex E2 component (dihydrolipoamide transsuccinylase); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Lipoate protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. | 0.624 |
GK2376 | GK2379 | GK2376 | GK2379 | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | 0.997 |
GK2376 | gcvH | GK2376 | GK3004 | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | Protein H involved in glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.583 |
GK2376 | lipA | GK2376 | GK2974 | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | Lipoic acid synthetase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.560 |
GK2376 | lipL | GK2376 | GK3414 | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | Hypothetical conserved protein; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.663 |
GK2376 | lipM | GK2376 | GK2420 | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | Lipoate protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. | 0.624 |
GK2379 | GK1024 | GK2379 | GK1024 | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | 2-oxoglutarate dehydrogenase complex E2 component (dihydrolipoamide transsuccinylase); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.996 |
GK2379 | GK2376 | GK2379 | GK2376 | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase). | 0.997 |
GK2379 | gcvH | GK2379 | GK3004 | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Protein H involved in glycine cleavage system; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.980 |
GK2379 | lipA | GK2379 | GK2974 | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Lipoic acid synthetase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.578 |
GK2379 | lipL | GK2379 | GK3414 | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Hypothetical conserved protein; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.551 |
GK2379 | lipM | GK2379 | GK2420 | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Lipoate protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. | 0.682 |
GK2379 | tkt | GK2379 | GK1332 | Branched-chain alpha-keto acid dehydrogenase E3 component (dihydrolipoamide dehydrogenase). | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.400 |
GK2975 | lipA | GK2975 | GK2974 | Hypothetical conserved protein. | Lipoic acid synthetase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.589 |