STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HSP60Heat shock protein 60, mitochondrial; May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity); Belongs to the chaperonin (HSP60) family. (566 aa)    
Predicted Functional Partners:
A0A1D8PFU8
Uncharacterized protein; Belongs to the GroES chaperonin family.
 
 
 0.999
SSC1
Heat shock protein SSC1, mitochondrial; Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein (By similarity).
  
 0.972
SSQ1
Hsp70 family ATPase; Belongs to the heat shock protein 70 family.
  
 0.930
MGE1
GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.
  
 0.916
COF1
Cofilin; Belongs to the actin-binding proteins ADF family.
 
 
  
 0.906
HSP78
Heat shock protein 78, mitochondrial; Required, in concert with mitochondrial Hsp70, for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP- dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress (By similarity). Belongs to the ClpA/ClpB family.
  
 
 0.905
SSA1
Heat shock protein SSA1; May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum.
  
 
 0.881
TCP1
Chaperonin-containing T-complex alpha subunit.
   
 
 0.879
KAR2
Hsp70 family ATPase; Belongs to the heat shock protein 70 family.
  
 
 0.864
MSI3
Heat shock protein homolog SSE1.
  
 
 0.864
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.