STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
icd1Isocitrate dehydrogenase, NADP-dependent; Identified by similarity to SP:P50214; match to protein family HMM PF00180; match to protein family HMM TIGR00183. (466 aa)    
Predicted Functional Partners:
acnA
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.990
sucA
2-oxoglutarate dehydrogenase, E1 component; Identified by match to protein family HMM PF00676; match to protein family HMM PF02779; match to protein family HMM TIGR00239.
   
 
 0.984
citZ
Citrate synthase 2; Identified by match to protein family HMM PF00285; match to protein family HMM TIGR01800; Belongs to the citrate synthase family.
 
 
 0.957
gdhA
Glutamate dehydrogenase; Identified by similarity to SP:P96110; match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.952
icd2
Isocitrate dehydrogenase; Identified by match to protein family HMM PF00180; match to protein family HMM TIGR02924.
 
0.944
ACP_1462
Putative isocitrate dehydrogenase, NAD-dependent; Identified by match to protein family HMM PF00180.
 
0.941
mdh
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 
 0.935
ACP_0328
2-oxoacid:ferredoxin/flavodoxin oxidoreductase gamma subunit family protein; Identified by match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR03710.
   
 
 0.934
ACP_0329
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by similarity to GB:BAA10899.1; match to protein family HMM PF02775.
     
 0.914
sucC
succinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.876
Your Current Organism:
Acidobacterium capsulatum
NCBI taxonomy Id: 240015
Other names: A. capsulatum ATCC 51196, Acidobacterium capsulatum ATCC 51196, Acidobacterium capsulatum str. ATCC 51196, Acidobacterium capsulatum strain ATCC 51196
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.