node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP_1004 | fhs | ACP_1004 | ACP_0733 | Homocysteine S-methyltransferase/methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.950 |
ACP_1004 | folD | ACP_1004 | ACP_3313 | Homocysteine S-methyltransferase/methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.944 |
ACP_1004 | gcvH | ACP_1004 | ACP_2097 | Homocysteine S-methyltransferase/methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.720 |
ACP_1004 | gcvPA | ACP_1004 | ACP_2098 | Homocysteine S-methyltransferase/methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Putative glycine cleavage system P-protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.435 |
ACP_1004 | gcvPB | ACP_1004 | ACP_2099 | Homocysteine S-methyltransferase/methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Putative glycine cleavage system P-protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.486 |
ACP_1004 | gcvT | ACP_1004 | ACP_2096 | Homocysteine S-methyltransferase/methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.952 |
ACP_1004 | glyA | ACP_1004 | ACP_2846 | Homocysteine S-methyltransferase/methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
ACP_1004 | metH | ACP_1004 | ACP_3337 | Homocysteine S-methyltransferase/methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.998 |
ACP_1004 | purH | ACP_1004 | ACP_3297 | Homocysteine S-methyltransferase/methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | Bifunctional purine biosynthesis protein PurH; Identified by similarity to SP:P15639; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.944 |
fhs | ACP_1004 | ACP_0733 | ACP_1004 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Homocysteine S-methyltransferase/methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | 0.950 |
fhs | folD | ACP_0733 | ACP_3313 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |
fhs | gcvH | ACP_0733 | ACP_2097 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.459 |
fhs | gcvPB | ACP_0733 | ACP_2099 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Putative glycine cleavage system P-protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.506 |
fhs | gcvT | ACP_0733 | ACP_2096 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.947 |
fhs | glyA | ACP_0733 | ACP_2846 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.961 |
fhs | metH | ACP_0733 | ACP_3337 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.946 |
fhs | purH | ACP_0733 | ACP_3297 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional purine biosynthesis protein PurH; Identified by similarity to SP:P15639; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.987 |
folD | ACP_1004 | ACP_3313 | ACP_1004 | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Homocysteine S-methyltransferase/methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574. | 0.944 |
folD | fhs | ACP_3313 | ACP_0733 | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.995 |
folD | gcvH | ACP_3313 | ACP_2097 | Methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.760 |