node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ava_1204 | Ava_1927 | Ava_1204 | Ava_1927 | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Dihydrolipoamide dehydrogenase. | 0.845 |
Ava_1204 | gcvH | Ava_1204 | Ava_2761 | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.802 |
Ava_1204 | gcvP | Ava_1204 | Ava_2762 | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.872 |
Ava_1204 | gcvT | Ava_1204 | Ava_2760 | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.806 |
Ava_1204 | purQ | Ava_1204 | Ava_0407 | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] | 0.906 |
Ava_1783 | Ava_1927 | Ava_1783 | Ava_1927 | succinyl-CoA synthetase (ADP-forming) beta subunit. | Dihydrolipoamide dehydrogenase. | 0.445 |
Ava_1783 | gcvP | Ava_1783 | Ava_2762 | succinyl-CoA synthetase (ADP-forming) beta subunit. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.890 |
Ava_1783 | gcvT | Ava_1783 | Ava_2760 | succinyl-CoA synthetase (ADP-forming) beta subunit. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.817 |
Ava_1927 | Ava_1204 | Ava_1927 | Ava_1204 | Dihydrolipoamide dehydrogenase. | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.845 |
Ava_1927 | Ava_1783 | Ava_1927 | Ava_1783 | Dihydrolipoamide dehydrogenase. | succinyl-CoA synthetase (ADP-forming) beta subunit. | 0.445 |
Ava_1927 | Ava_5058 | Ava_1927 | Ava_5058 | Dihydrolipoamide dehydrogenase. | Alanine-glyoxylate aminotransferase apoenzyme. | 0.903 |
Ava_1927 | gcvH | Ava_1927 | Ava_2761 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.988 |
Ava_1927 | gcvP | Ava_1927 | Ava_2762 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.954 |
Ava_1927 | gcvT | Ava_1927 | Ava_2760 | Dihydrolipoamide dehydrogenase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.970 |
Ava_1927 | glyA | Ava_1927 | Ava_2076 | Dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
Ava_1927 | purQ | Ava_1927 | Ava_0407 | Dihydrolipoamide dehydrogenase. | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] | 0.802 |
Ava_4955 | Ava_5058 | Ava_4955 | Ava_5058 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | Alanine-glyoxylate aminotransferase apoenzyme. | 0.932 |
Ava_4955 | gcvP | Ava_4955 | Ava_2762 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.941 |
Ava_4955 | glyA | Ava_4955 | Ava_2076 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.932 |
Ava_5058 | Ava_1927 | Ava_5058 | Ava_1927 | Alanine-glyoxylate aminotransferase apoenzyme. | Dihydrolipoamide dehydrogenase. | 0.903 |