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gyrA protein (Porphyromonas gingivalis W83) - STRING interaction network
"gyrA" - DNA gyrase subunit A in Porphyromonas gingivalis W83
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (859 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (654 aa)
  0.999
PG_0368
DNA topoisomerase IV subunit B (644 aa)
  0.996
dnaN
DNA polymerase III subunit beta; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (377 aa)
   
  0.974
dnaK
dnaK protein; Acts as a chaperone (640 aa)
 
  0.833
PG_1385
Hypothetical protein (400 aa)
         
  0.830
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP (506 aa)
     
   
  0.826
PG_1636
FtsK/SpoIIIE family protein (861 aa)
     
 
  0.816
nrd
Ribonucleotide reductase (850 aa)
   
   
  0.804
recQ-2
ATP-dependent DNA helicase RecQ (655 aa)
   
  0.798
recQ-1
ATP-dependent DNA helicase RecQ (725 aa)
   
  0.798
Your Current Organism:
Porphyromonas gingivalis W83
NCBI taxonomy Id: 242619
Other names: P. gingivalis W83, Porphyromonas gingivalis W83, Porphyromonas gingivalis str. W83, Porphyromonas gingivalis strain W83
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