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folA protein (Porphyromonas gingivalis W83) - STRING interaction network
"folA" - Dihydrofolate reductase in Porphyromonas gingivalis W83
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (162 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Provides the sole de novo source of dTMP for DNA biosynthesis (267 aa)
 
  0.999
folC
Folylpolyglutamate synthase (429 aa)
   
  0.990
ribD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5’-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5’-phosphate (330 aa)
       
  0.902
folK
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (149 aa)
 
   
  0.882
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (426 aa)
   
  0.881
gcvP
Glycine dehydrogenase (955 aa)
       
  0.844
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine (362 aa)
   
 
  0.834
folP
Dihydropteroate synthase (281 aa)
   
 
  0.833
pdhD
Alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase (449 aa)
   
 
  0.825
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (126 aa)
       
    0.806
Your Current Organism:
Porphyromonas gingivalis W83
NCBI taxonomy Id: 242619
Other names: P. gingivalis W83, Porphyromonas gingivalis W83, Porphyromonas gingivalis str. W83, Porphyromonas gingivalis strain W83
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