node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PG_0474 | PG_0475 | PG_0474 | PG_0475 | Low-specificity L-threonine aldolase; Similar to GB:L29636, SP:P38133, and PID:532251; identified by sequence similarity; putative. | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.677 |
PG_0474 | panC | PG_0474 | PG_0477 | Low-specificity L-threonine aldolase; Similar to GB:L29636, SP:P38133, and PID:532251; identified by sequence similarity; putative. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.677 |
PG_0474 | yngK-2 | PG_0474 | PG_0476 | Low-specificity L-threonine aldolase; Similar to GB:L29636, SP:P38133, and PID:532251; identified by sequence similarity; putative. | yngK protein; Similar to SP:P34024, GB:X54618, GB:X60035, and PID:581304; identified by sequence similarity; putative. | 0.648 |
PG_0475 | PG_0474 | PG_0475 | PG_0474 | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Low-specificity L-threonine aldolase; Similar to GB:L29636, SP:P38133, and PID:532251; identified by sequence similarity; putative. | 0.677 |
PG_0475 | panC | PG_0475 | PG_0477 | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.802 |
PG_0475 | yngK-2 | PG_0475 | PG_0476 | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | yngK protein; Similar to SP:P34024, GB:X54618, GB:X60035, and PID:581304; identified by sequence similarity; putative. | 0.818 |
cmk | guaA | PG_0603 | PG_0589 | Cytidylate kinase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.620 |
cmk | panC | PG_0603 | PG_0477 | Cytidylate kinase. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.906 |
coaBC | coaX | PG_1851 | PG_0447 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.922 |
coaBC | panC | PG_1851 | PG_0477 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.882 |
coaX | coaBC | PG_0447 | PG_1851 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.922 |
coaX | panC | PG_0447 | PG_0477 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.961 |
coaX | panD | PG_0447 | PG_1114 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.638 |
guaA | cmk | PG_0589 | PG_0603 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Cytidylate kinase. | 0.620 |
guaA | panB | PG_0589 | PG_0588 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.861 |
guaA | panC | PG_0589 | PG_0477 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.641 |
panB | guaA | PG_0588 | PG_0589 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.861 |
panB | panC | PG_0588 | PG_0477 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.995 |
panB | panD | PG_0588 | PG_1114 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.849 |
panB | panE | PG_0588 | PG_2205 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.931 |