STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
PG_1424Peptidylarginine deiminase; Deiminates the guanidino group of C-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. May promote the growth of the pathogen in the periodontal pocket by producing ammonia, ammonia having a protective effect during acidic cleaning cycles in the mouth. (556 aa)    
Predicted Functional Partners:
PG_0144
Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the agmatine deiminase family.
  
  
 0.970
PG_0143
Hydrolase, carbon-nitrogen family.
 
 
 0.951
PG_0903
Conserved hypothetical protein; Identified by match to TIGR protein family HMM TIGR00286.
    
  0.900
prtRII
Arginine-specific cysteine proteinase; Thiol protease. Acts synergistically with RgpA to catalyze the maturation of fimbrial subunits, such as FimA (By similarity). Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (Probable).
 
   
 0.888
PG_0410
Hypothetical protein; Identified by Glimmer2; putative.
  
   
 0.766
hagE
Hemagglutinin protein HagE; Cleaves human complement component C3. May enable P.gingivalis to evade complement-mediated killing during the immune response. Plays an important role in soft tissue infections and is a virulence factor; Belongs to the peptidase C25 family.
 
     0.703
dacB
D-alanyl-D-alanine carboxypeptidase; Similar to GB:L10393, SP:P08048, SP:P17010, and PID:340436; identified by sequence similarity; putative.
       0.623
PG_1423
Hypothetical protein; Identified by Glimmer2; putative.
       0.623
hagA
Hemagglutinin protein HagA; Agglutinates erythrocytes.
  
   
 0.571
PG_0232
Zinc carboxypeptidase, putative.
 
   
 0.557
Your Current Organism:
Porphyromonas gingivalis
NCBI taxonomy Id: 242619
Other names: P. gingivalis W83, Porphyromonas gingivalis W83, Porphyromonas gingivalis str. W83, Porphyromonas gingivalis strain W83
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