STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hagAHemagglutinin protein HagA; Agglutinates erythrocytes. (2105 aa)    
Predicted Functional Partners:
hagE
Hemagglutinin protein HagE; Cleaves human complement component C3. May enable P.gingivalis to evade complement-mediated killing during the immune response. Plays an important role in soft tissue infections and is a virulence factor; Belongs to the peptidase C25 family.
  
 
 
0.838
PG_2174
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.729
PG_0093
HlyD family secretion protein.
  
 
 0.633
porT
porT protein.
  
   
 0.611
PG_0602
Hypothetical protein; Identified by Glimmer2; putative.
  
    0.610
PG_1424
Peptidylarginine deiminase; Deiminates the guanidino group of C-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. May promote the growth of the pathogen in the periodontal pocket by producing ammonia, ammonia having a protective effect during acidic cleaning cycles in the mouth.
  
   
 0.571
PG_0283
Efflux transporter, MFP component, RND family; Similar to GB:D28503, PID:556484, and SP:Q59295; identified by sequence similarity; putative.
   
 
 0.564
PG_0026
Hypothetical protein; Identified by Glimmer2; putative.
  
   
 0.553
fimA
Fimbrilin; Structural subunit of the major fimbriae. These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome. They play an important role in the invasion of periodontal tissues. Fimbriae and their constituents are major virulence factors. FimA proteins from different strains have highly divergent sequences, and this has been used for classification. The sequence-based classification correlates with pathogenicity; Belongs to the bacteroidetes fimbrillin superfamil [...]
      
 0.550
PG_0534
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.543
Your Current Organism:
Porphyromonas gingivalis
NCBI taxonomy Id: 242619
Other names: P. gingivalis W83, Porphyromonas gingivalis W83, Porphyromonas gingivalis str. W83, Porphyromonas gingivalis strain W83
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