STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (539 aa)    
Predicted Functional Partners:
guaA-2
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 0.999
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.991
purH
Bifunctional purine biosynthesis protein purH; PMID: 3036807 best DB hits: BLAST: swissprot:P12048; PUR9_BACSU BIFUNCTIONAL PURINE BIOSYNTHESIS; E=1e-125 ddbj:BAB04352.1; (AP001509); E=1e-124 gb:AAF33520.1; (AF170176) Salmonella typhimurium; E=1e-118 COG: BS_purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-126 purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP; E=1e-119 HI0887; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-118 PFAM: PF02142; MGS-like domain; E=2.2e-46 PF01808; AICARFT/IMPCHase bienzyme; E=1.3e-113.
  
 
 0.973
hpt
Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...]
    
 0.944
surE
Acid phosphatase SurE; PMID: 8905231 best DB hits: BLAST: swissprot:P73440; YE59_SYNY3 HYPOTHETICAL 24.9 KD PROTEIN SLL1459; E=4e-31 swissprot:O83434; SURE_TREPA STATIONARY-PHASE SURVIVAL PROTEIN; E=3e-22 gb:AAD51394.1; AF117715_3 (AF117715) survival protein homolog; E=4e-20 COG: sll1459; COG0496 Survival protein, predicted acid phosphatase; E=4e-32 PFAM: PF01975; Survival protein SurE; E=9.8e-49.
 
  
 0.936
surE-2
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
 
  
 0.936
RB5134
Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 0.933
RB1934
Alkaline phosphatase; PMID: 1712356 best DB hits: BLAST: pir:A47026; alkaline phosphatase, 145K - Synechococcus sp. (strain PCC; E=0.0 pir:S74916; alkaline phosphatase - Synechocystis sp. (strain PCC 6803); E=1e-108 pir:A69809; probable multifunctional phosphoesterase (EC 3.1.-.-) yfkN; E=5e-22 COG: sll0654_2; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase; E=8e-99 DRA0018; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and; E=1e-22 BS_yfkN_2; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase; E=4e-22 PFAM: PF01009; 5'-nucleotidase, catalytic do; E=1e-32 PF02872; 5 [...]
    
 0.919
purF
Amidophosphoribosyltransferase [precursor]; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 
 0.908
purB
Adenylosuccinate lyase; PMID: 96015068 PMID: 2111814 best DB hits: BLAST: gb:AAB60684.1; (U20225) adenylosuccinate lyase [Mus musculus]; E=1e-144 gb:AAC83935.1; (AF106656) adenylosuccinate lyase [Homo sapiens]; E=1e-140 gb:AAH00253.1; AAH00253 (BC000253) adenylosuccinate lyase [Homo; E=1e-140 COG: YLR359w; COG0015 Adenylosuccinate lyase; E=1e-132 PFAM: PF00206; Lyase; E=2.5e-57; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.894
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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