STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RB11985Quinone oxidoreductase; PMID: 11058132 PMID: 7602590 PMID: 1420281 best DB hits: BLAST: ddbj:BAB04654.1; (AP001510) quinone oxidoreductase [Bacillus; E=2e-43 embl:CAB65629.1; (AL136149) putative oxidoreductase; E=1e-31 swissprot:P11415; QOR_CAVPO QUINONE OXIDOREDUCTASE (NADPH:QUINONE; E=3e-31 COG: BH0935; COG0604 NADPH:quinone reductase and related Zn-dependent; E=2e-44 PA5427; COG1064 Zn-dependent alcohol dehydrogenases; E=6e-15 BH0738; COG0604 NADPH:quinone reductase and related Zn-dependent; E=5e-14 PFAM: PF00106; short chain dehydrogenase; E=0.46 PF00107; Zinc-binding dehydrogenase [...] (335 aa)    
Predicted Functional Partners:
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
       0.773
RB6500
Mycocerosate synthase; PMID: 3880746 best DB hits: BLAST: pir:S72705; mycocerosate synthase (EC 2.3.1.111) - Mycobacterium; E=0.0 pir:H70819; probable polyketide synthase - Mycobacterium tuberculosis; E=0.0 gb:AAF62883.1; AF217189_6 (AF217189) epoD [Sorangium cellulosum]; E=1e-180 COG: PA2402_3; COG1020 Non-ribosomal peptide synthetase modules and related; E=4e-99 BS_ppsD_3; COG1020 Non-ribosomal peptide synthetase modules and; E=4e-92 PA2424_2; COG1020 Non-ribosomal peptide synthetase modules and related; E=1e-91 PFAM: PF00108; Thiolase, N-terminal domain; E=2.7e-06 PF00109; Beta-keto [...]
  
 
0.615
RB11975
Polyketide synthase; PMID: 10662695 PMID: 10649995 best DB hits: BLAST: gb:AAF26921.1; AF210843_18 (AF210843) polyketide synthase [Sorangium; E=0.0 gb:AAF26923.1; AF210843_20 (AF210843) polyketide synthase [Sorangium; E=0.0 gb:AAF62883.1; AF217189_6 (AF217189) epoD [Sorangium cellulosum]; E=0.0 COG: BS_fabD; COG0331 (acyl-carrier-protein) S-malonyltransferase; E=7e-31 PA2965; COG0304 3-oxoacyl-(acyl-carrier-protein) synthase I; E=3e-28 PA5234; COG0604 NADPH:quinone reductase and related Zn-dependent; E=2e-27 PFAM: PF00108; Thiolase, N-terminal domain; E=7.3e-07 PF00109; Beta-ketoacyl s [...]
  
 
0.613
RB11991
Conserved hypothetical protein-putative histone deacetylase; PMID: 10567266 PMID: 7678591 PMID: 7934817 best DB hits: BLAST: swissprot:P28606; YGLA_SYNP2 HYPOTHETICAL 34.1 KD PROTEIN IN GLNA; E=5e-60 embl:CAA78368.1; (Z13965) Portion of hypothetical protein; E=5e-60 embl:CAA78369.1; (Z13965) Portion of hypothetical protein; E=2e-54 COG: DR0833; COG0123 Deacetylases, including yeast histone deacetylase; E=3e-51 PFAM: PF00850; Histone deacetylase family; E=1.2e-50.
   
   0.578
RB11986
Histidine protein kinase homolog GacS; PMID: 10762268 best DB hits: BLAST: gb:AAF04854.1; AF197912_1 (AF197912) histidine protein kinase; E=3e-57 pir:E83212; probable sensorresponse regulator hybrid PA3462; E=4e-56 pir:H83132; probable sensorresponse regulator hybrid PA4112; E=8e-51 COG: PA3462; COG0642 Sensory transduction histidine kinases; E=3e-57 PFAM: PF00989; PAS domain; E=3.5e-07 PF00512; His Kinase A (phosphoacceptor; E=2.5e-21 PF02518; Histidine kinase-, DNA gyrase; E=6.8e-39.
  
  
 0.569
RB11988
Probable serine/threonine-protein kinase pknB; PMID: 11410353 PMID: 11856348 PMID: 8969512 PMID: 11234002 best DB hits: BLAST: swissprot:P54744; PKNB_MYCLE PUTATIVE SERINETHREONINE-PROTEIN; E=2e-33 swissprot:P71584; PKNB_MYCTU PUTATIVE SERINETHREONINE-PROTEIN; E=3e-33 swissprot:Q11053; PKNH_MYCTU PROBABLE SERINETHREONINE-PROTEIN; E=7e-29 COG: Rv0014c_1; COG0515 Serine/threonine protein kinases; E=3e-34 PFAM: PF00069; Protein kinase domain; E=6.5e-41.
       0.563
RB11990
Best DB hits: PFAM: PF00140; Sigma-70 factor; E=0.0091 PF00196; Bacterial regulatory proteins, l; E=0.0013.
       0.563
RB10446
Beta keto-acyl synthase; Best DB hits: BLAST: ddbj:BAA89384.1; (AB025342) ORF10 [Moritella marina]; E=3e-37 pir:T30185; hypothetical protein 7 - Shewanella sp ----- gb:; E=3e-36 pir:T37057; probable multi-domain beta keto-acyl synthase -; E=8e-35 COG: DR1945; COG0331 (acyl-carrier-protein) S-malonyltransferase; E=3e-17 Rv3391_1; COG0451 Nucleoside-diphosphate-sugar epimerases; E=2e-14 BH2492; COG0331 (acyl-carrier-protein) S-malonyltransferase; E=2e-13 PFAM: PF00109; Beta-ketoacyl synthase, N-ter; E=7.7e-09 PF02801; Beta-ketoacyl synthase, C-ter; E=7.6e-61 PF00109; Beta-ketoacyl syntha [...]
  
 
 0.535
adh-2
PMID: 4578954 best DB hits: BLAST: pir:G72376; alcohol dehydrogenase, zinc-containing - Thermotoga; E=7e-23 gb:AAF17283.1; (AF204805) NosE [Nostoc sp. GSV224]; E=9e-19 ddbj:BAB10455.1; (AB005234) alcohol dehydrogenase-like protein; E=1e-18 COG: TM0436; COG1063 Threonine dehydrogenase and related Zn-dependent; E=7e-24 NMB0546; COG1064 Zn-dependent alcohol dehydrogenases; E=3e-15 PA2188; COG1063 Threonine dehydrogenase and related Zn-dependent; E=3e-15 PFAM: PF00899; ThiF family; E=0.34 PF02032; Phytoene dehydrogenase related; E=0.1 PF01494; FAD binding domain; E=0.0065.
  
     0.432
RB386
Saframycin Mx1 synthetase B; PMID: 8936303 best DB hits: BLAST: pir:T18551; saframycin Mx1 synthetase B - Myxococcus xanthus -----; E=1e-112 pir:T34918; polyketide synthase - Streptomyces coelicolor -----; E=1e-102 pir:H83343; probable non-ribosomal peptide synthetase PA2424; E=1e-101 COG: PA2424_1; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid; E=1e-102 Rv1529; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases; E=7e-83 Ta1189; COG0156 7-keto-8-aminopelargonate synthetase and related; E=6e-62 PFAM: PF00501; AMP-binding enzyme; E=2.2e-08 PF00550; Phosphopantetheine attac [...]
  
  
 0.429
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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