STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
enoEnolase (2-phosphoglycerate dehydratase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)    
Predicted Functional Partners:
pykA
Pyruvate kinase; PMID: 9387221 best DB hits: BLAST: ddbj:BAB06882.1; (AP001517) pyruvate kinase [Bacillus halodurans]; E=4e-82 swissprot:P80885; KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE; E=6e-80 swissprot:P51181; KPYK_BACLI PYRUVATE KINASE (PK) ----- pir:; E=1e-79 COG: BH3163_1; COG0469 Pyruvate kinase; E=4e-83 PFAM: PF00478; IMP dehydrogenase; Belongs to the pyruvate kinase family.
 
 0.993
pgm
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
 
 0.992
pgk
Phosphoglycerate kinase; PMID: 8021172 best DB hits: BLAST: swissprot:P40924; PGK_BACSU PHOSPHOGLYCERATE KINASE ----- pir:; E=3e-96 swissprot:O52632; PGK_CLOAB PHOSPHOGLYCERATE KINASE -----gb:; E=4e-96 swissprot:P29409; PGKH_SPIOL PHOSPHOGLYCERATE KINASE, CHLOROPLAST; E=2e-93 COG: BS_pgk; COG0126 3-phosphoglycerate kinase; E=3e-97 PFAM: PF00162; Phosphoglycerate kinase; E=8.3e-186; Belongs to the phosphoglycerate kinase family.
 
 
 0.988
pgi
Glucose-6-phosphate isomerase; PMID: 2549364 best DB hits: BLAST: swissprot:P80860; G6PI_BACSU GLUCOSE-6-PHOSPHATE ISOMERASE (GPI); E=6e-53 ddbj:BAB07062.1; (AP001518) glucose-6-phosphate isomerase; E=4e-52 pir:S15937; glucose-6-phosphate isomerase (EC 5.3.1.9) - Bacillus; E=5e-52 COG: BS_pgi; COG0166 Glucose-6-phosphate isomerase; E=6e-54 PFAM: PF00342; Phosphoglucose isomerase; E=6.8e-31.
  
 0.982
RB2627
Glyceraldehyde 3-phosphate dehydrogenase; PMID: 8557349 best DB hits: BLAST: swissprot:O06822; G3P_MYCTU GLYCERALDEHYDE 3-PHOSPHATE; E=2e-99 swissprot:P46795; G3P_BORBU GLYCERALDEHYDE 3-PHOSPHATE; E=2e-99 swissprot:P46713; G3P_MYCLE GLYCERALDEHYDE 3-PHOSPHATE; E=6e-99 COG: Rv1436; COG0057 Glyceraldehyde-3-phosphate; E=1e-101 PFAM: PF01408; Oxidoreductase family, NAD-bindi; E=0.11 PF00044; Glyceraldehyde 3-phosphate dehyd; E=2.2e-118 PF02800; Glyceraldehyde 3-phosphate dehyd; E=5.5e-109; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
 
 
 0.979
fba
Fructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
  
 0.979
rplD
50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
 
 0.975
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
 
 0.956
tkt
Transketolase; PMID: 7859749 best DB hits: BLAST: swissprot:P45694; TKT_BACSU TRANSKETOLASE ----- pir: G69723; E=1e-171 ddbj:BAB06071.1; (AP001515) transketolase [Bacillus halodurans]; E=1e-169 swissprot:Q43848; TKTC_SOLTU TRANSKETOLASE, CHLOROPLAST PRECURSOR; E=1e-164 COG: BS_tkt; COG0021 Transketolase; E=1e-172 PFAM: PF00456; Transketolase, thiamine dipho; E=1.1e-160 PF02779; Transketolase, central domain; E=1.2e-77 PF02780; Transketolase, C-terminal dom; E=1.1e-49; Belongs to the transketolase family.
   
 0.942
ppdK
Pyruvate,phosphate dikinase; PMID: 2176881 best DB hits: BLAST: pir:F72397; pyruvate,orthophosphate dikinase (EC 2.7.9.1) -; E=0.0 swissprot:P22983; PODK_CLOSY PYRUVATE,PHOSPHATE DIKINASE; E=0.0 pdb:1DIK; Pyruvate Phosphate Dikinase; E=0.0 COG: TM0272; COG0574 Phosphoenolpyruvate synthase; E=0.0 PA3562_3; COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI; E=2e-27 MTH1118; COG0574 Phosphoenolpyruvate synthase; E=1e-22 PFAM: PF01326; Pyruvate phosphate dikinase,; E=1.1e-167 PF00391; PEP-utilizing enzyme, mobile; E=4.1e-37 PF02896; PEP-utilizing enzyme, TIM bar; E=3e-141; Belongs [...]
   
 0.939
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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