STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdARibonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen (By similarity). (1040 aa)    
Predicted Functional Partners:
RB5675
Probable transcriptional regulator; Best DB hits: BLAST: embl:CAB72194.1; (AL138851) hypothetical protein SCE59.07c; E=3e-10 gb:AAG15555.1; (AY007523) AlgH [Pseudomonas fluorescens]; E=6e-06 pir:C83596; conserved hypothetical protein PA0405 [imported] -; E=6e-06 COG: PA0405; COG1678 Putative transcriptional regulator; E=6e-07 PFAM: PF02622; Uncharacterized ACR, COG1678; E=4.1e-12; Belongs to the UPF0301 (AlgH) family.
  
 0.990
RB10007
Conserved hypothetical protein; Best DB hits: BLAST: gb:AAF97283.1; AC010164_5 (AC010164) Unknown protein [Arabidopsis; E=0.087 pir:B82584; transcription regulator XF2228 [imported] - Xylella; E=0.32 pir:T10016; hypothetical protein - Mycobacterium leprae -----; E=0.64; Belongs to the UPF0301 (AlgH) family.
   
 0.985
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.940
cmk
Cytidylate kinase; PMID: 9126287 best DB hits: BLAST: swissprot:Q49885; KCY_MYCLE CYTIDYLATE KINASE (CK) (CYTIDINE; E=2e-30 swissprot:Q9RC80; KCY_BACHD CYTIDYLATE KINASE (CK) (CYTIDINE; E=5e-30 pir:S75604; pantothenate synthetase panC - Synechocystis sp. (strain; E=3e-29 COG: BH1634; COG0283 Cytidylate kinase; E=5e-31 PFAM: PF02223; Thymidylate kinase; E=0.42 PF00485; Phosphoribulokinase / Uridine; E=0.094 PF01202; Shikimate kinase; E=3.5e-05.
  
 
 0.923
ndk
Nucleoside diphosphate kinase (NDK); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.921
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.912
adk-2
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.912
pykA
Pyruvate kinase; PMID: 9387221 best DB hits: BLAST: ddbj:BAB06882.1; (AP001517) pyruvate kinase [Bacillus halodurans]; E=4e-82 swissprot:P80885; KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE; E=6e-80 swissprot:P51181; KPYK_BACLI PYRUVATE KINASE (PK) ----- pir:; E=1e-79 COG: BH3163_1; COG0469 Pyruvate kinase; E=4e-83 PFAM: PF00478; IMP dehydrogenase; Belongs to the pyruvate kinase family.
     
 0.911
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.892
dnaN
DNA polymerase III, beta chain; PMID: 2540413 best DB hits: BLAST: swissprot:P13455; DP3B_PSEPU DNA POLYMERASE III, BETA CHAIN; E=1e-31 pir:C81713; DNA polymerase III, beta chain TC0347 [imported] -; E=1e-29 pir:E71559; probable DNA pol III (beta chain) - Chlamydia; E=1e-29 COG: CT075; COG0592 DNA polymerase III beta subunit; E=1e-30 PFAM: PF00712; DNA polymerase III beta subun; E=7.1e-16 PF02767; DNA polymerase III beta subun; E=2.4e-12 PF02768; DNA polymerase III beta subun; E=1e-10.
 
 
 0.882
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
Server load: medium (78%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.