STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pknB-3Probable serine/threonine-protein kinase pknB; Best DB hits: BLAST: swissprot:P71584; PKNB_MYCTU PUTATIVE SERINETHREONINE-PROTEIN; E=3e-40 pir:H69878; probable protein kinase (EC 2.7.1.-) yloP - Bacillus; E=9e-38 swissprot:P54744; PKNB_MYCLE PUTATIVE SERINETHREONINE-PROTEIN; E=2e-37 COG: Rv0014c_1; COG0515 Serine/threonine protein kinases; E=3e-41 PFAM: PF00069; Protein kinase domain; E=2e-47. (783 aa)    
Predicted Functional Partners:
RB10333
Protein kinase homolog; Best DB hits: BLAST: pir:T42076; protein kinase homolog - Streptomyces coelicolor -----; E=5e-18 pir:T42077; protein kinase homolog - Streptomyces coelicolor -----; E=1e-16 pir:T35491; probable serinethreonine-specific protein kinase pkaF -; E=1e-16 COG: Rv0014c_1; COG0515 Serine/threonine protein kinases; E=3e-15 PFAM: PF00069; Protein kinase domain; E=3.2e-06.
  
   
 0.906
Pph1
Probable protein phosphatase 1; PMID: 11298281 best DB hits: BLAST: gb:AAF81068.1; AF223364_3 (AF223364) protein phosphatase 1; E=9e-32 pir:E71538; hypothetical protein CT259 - Chlamydia trachomatis; E=4e-28 pir:H75265; conserved hypothetical protein - Deinococcus radiodurans; E=5e-28 COG: CT259; COG0631 Protein serine/threonine phosphatases; E=4e-29 PFAM: PF00481; Protein phosphatase 2C; E=4.9e-09.
  
   0.797
RB3245
Protein phosphatase 1; PMID: 11298281 best DB hits: BLAST: gb:AAF81068.1; AF223364_3 (AF223364) protein phosphatase 1; E=3e-27 pir:E71538; hypothetical protein CT259 - Chlamydia trachomatis; E=5e-26 embl:CAA10712.1; (AJ132604) pppL protein [Lactococcus lactis]; E=2e-25 COG: CT259; COG0631 Protein serine/threonine phosphatases; E=4e-27 PFAM: PF00481; Protein phosphatase 2C; E=1.2e-09.
  
   0.794
RB5876
Probable serine/threonine-protein kinase; PMID: 7768349 best DB hits: BLAST: swissprot:P54737; PKN5_MYXXA SERINETHREONINE-PROTEIN KINASE PKN5; E=3e-09 gb:AAF87930.1; AF163841_9 (AF163841) putative serinethreonine; E=4e-09 swissprot:P54738; PKN6_MYXXA SERINETHREONINE-PROTEIN KINASE PKN6; E=1e-07 COG: Rv0014c_1; COG0515 Serine/threonine protein kinases; E=1e-07 PFAM: PF00069; Protein kinase domain; E=3.8e-08 PF01130; CD36 family; E=0.61.
  
     0.728
acs
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
       0.655
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
      
 0.544
pkn2-2
Putative serine/threonine-protein kinase; PMID: 7774814 best DB hits: BLAST: embl:CAB94054.1; (AL358672) putative serinethreonine-protein; E=9e-43 swissprot:P54736; PKN2_MYXXA SERINETHREONINE-PROTEIN KINASE PKN2; E=4e-39 swissprot:Q10697; PKNJ_MYCTU PROBABLE SERINETHREONINE-PROTEIN; E=2e-38 COG: Rv2088; COG0515 Serine/threonine protein kinases; E=2e-39 PFAM: PF00069; Protein kinase domain; E=1.6e-54.
  
  
0.486
RB6417
Conserved hypothetical protein-putative FHA domain; PMID: 9634230 PMID: 7482699 best DB hits: BLAST: pir:B70700; hypothetical protein Rv0020c - Mycobacterium; E=8e-06 pir:T10015; hypothetical protein MLB1770.15c - Mycobacterium leprae; E=4e-05 ddbj:BAB20624.1; (AB052847) adenylate cyclase; E=0.001 COG: Rv0020c_2; COG1716 FHA-domain-containing proteins; E=4e-06 PFAM: PF00498; FHA domain; E=8.9e-17.
  
 
 
 0.478
gluQ
glutamyl-tRNA synthetase-related protein; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
       0.476
asnS
asparaginyl-tRNA synthetase; PMID: 2693216 PMID: 1425658 PMID: 2009959 PMID: 1544480 best DB hits: BLAST: swissprot:P52276; SYN_SYNY3 PROBABLE ASPARAGINYL-TRNA SYNTHETASE; E=1e-151 gb:AAK02727.1; (AE006100) AsnS [Pasteurella multocida]; E=1e-150 pir:E82217; asparaginyl-tRNA synthetase VC1297 [imported] - Vibrio; E=1e-148 COG: sll0495; COG0017 Aspartyl/asparaginyl-tRNA synthetases; E=1e-152 PFAM: PF01336; OB-fold nucleic acid binding dom; E=6.8e-15 PF01409; tRNA synthetases class II (F); E=0.025 PF00152; tRNA synthetases class II (D, K; E=1.3e-132.
       0.476
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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