STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nadKProbable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (311 aa)    
Predicted Functional Partners:
nadE
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.943
nadD
Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.937
cobT
Probable nicotinic acid mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.
  
 
 0.922
dxs
1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
    
 0.917
RB12291
Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10.
     
 0.914
pntA
NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: prf:2102322A; energy-transducing nicotinamide nucleotide; E=8e-76 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=9e-74 gb:AAK00588.1; (AY026033) pyridine nucleotide transhydrogenase; E=1e-72 COG: slr1239; COG3288 NAD/NADP transhydrogenase alpha subunit; E=9e-75 BH2329; COG0686 Alanine dehydrogenase; E=4e-26 PFAM: PF01266; D-amino acid oxidase; E=0.05 PF00070; Pyridine nucleotide-disulphide oxid; E=0.00011 PF01262; Alanine dehydrogenase/pyridine nucl; E=5.4e-89.
     
 0.914
pntB
NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.907
sthA
PMID: 9922271 best DB hits: BLAST: swissprot:P27306; STHA_ECOLI SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-154 swissprot:Q9XBQ9; STHA_AZOVI SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-149 swissprot:P50529; STHA_VIBCH SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-146 COG: VC0151; COG1249 Dihydrolipoamide dehydrogenase/glutathione; E=1e-147 PFAM: PF00070; Pyridine nucleotide-disulphide; E=6.5e-63 PF02852; Pyridine nucleotide-disulphide; E=1.6e-34.
     
 0.907
ggpP
PMID: 8016276,10617198 best DB hits: BLAST: pir:S74538; geranylgeranyl pyrophosphate synthase - Synechocystis; E=3e-37 ddbj:BAA82613.1; (AB016093) geranylgeranyl diphosphate synthase; E=1e-36 embl:CAC10561.1; (AJ249453) gpp synthase large subunit [Mentha x; E=1e-35 COG: slr0739; COG0142 Geranylgeranyl pyrophosphate synthase; E=3e-38 PFAM: PF00348; Polyprenyl synthetase; E=1.6e-83; Belongs to the FPP/GGPP synthase family.
 
 
   0.828
xseB
Similar to exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family.
       0.794
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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