STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
queEConserved hypothetical protein-putative radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (257 aa)    
Predicted Functional Partners:
queC
Probable transcription regulator; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
 
 0.996
RB5135
6-pyruvoyl tetrahydrobiopterin synthase; Best DB hits: BLAST: swissprot:Q9ZDY5; Y178_RICPR HYPOTHETICAL PROTEIN RP178 -----; E=2e-23 pir:E81913; hypothetical protein NMA0704 [imported] - Neisseria; E=3e-12 pir:G81189; 6-pyruvoyl tetrahydrobiopterin synthase, probable; E=7e-12 COG: RP178; COG0720 6-pyruvoyl-tetrahydropterin synthase; E=2e-24 PFAM: PF01242; 6-pyruvoyl tetrahydropterin synthase; E=1.2e-09.
 
 
 0.994
RB8806
Conserved hypothetical protein-putative 6-pyruvoyl-tetrahydropterin synthase; Best DB hits: BLAST: embl:CAC12079.1; (AL445066) conserved hypothetical protein; E=2e-11 swissprot:Q58668; YC72_METJA HYPOTHETICAL PROTEIN MJ1272 -----; E=1e-10 swissprot:O27296; YC28_METTH HYPOTHETICAL PROTEIN MTH1228 -----; E=2e-10 COG: Ta0950; COG0720 6-pyruvoyl-tetrahydropterin synthase; E=1e-12 PFAM: PF01242; 6-pyruvoyl tetrahydropterin synthas; E=0.0016 PF01945; Domain of unknown function; E=0.87.
  
 
 0.983
queF
Conserved hypothetical protein-putative GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
 
  
 0.973
RB2640
Hypothetical protein-signal peptide prediction.
       0.553
folE
GTP cyclohydrolase I; PMID: 1551827 PMID: 95352066 best DB hits: BLAST: swissprot:P19465; GCH1_BACSU GTP CYCLOHYDROLASE I (GTP-CH-I); E=1e-59 ddbj:BAB05365.1; (AP001512) GTP cyclohydrolase I [Bacillus; E=1e-57 swissprot:O06273; GCH1_MYCTU GTP CYCLOHYDROLASE I (GTP-CH-I); E=4e-53 COG: BS_mtrA; COG0302 GTP cyclohydrolase I; E=1e-60 PFAM: PF01227; GTP cyclohydrolase I; E=2.3e-110.
  
  
 0.520
guaA-2
GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.473
RB6226
PMID: 10984043 best DB hits: BLAST: pir:D83026; conserved hypothetical protein PA4950 [imported] -; E=4e-52 swissprot:P39288; YJES_ECOLI HYPOTHETICAL 43.1 KD PROTEIN IN; E=1e-48 gb:AAG59362.1; AE005650_1 (AE005650) orf, hypothetical protein; E=2e-48 COG: PA4950; COG1600 Uncharacterized Fe-S protein; E=4e-53 PFAM: PF00037; 4Fe-4S binding domain; E=0.026.
 
   
 0.463
moaA
Molybdopterin cofactor synthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
  
  
 0.408
tgt
Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...]
     
 0.402
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.