STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gyrBDNA gyrase subunit B; PMID: 8863738 best DB hits: BLAST: gb:AAF89615.1; AF167433_1 (AF167433) gyrase B [Thermus; E=5e-18 pir:JC4960; DNA topoisomerase (ATP-hydrolyzing) (EC 5.99.1.3) B -; E=1e-16 swissprot:P77993; GYRB_THEMA DNA GYRASE SUBUNIT B (TOPOISOMERASE; E=1e-16 COG: TM0833; COG0187 DNA gyrase (topoisomerase II) B subunit; E=1e-17 PFAM: PF01751; Toprim domain; E=0.81. (243 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase subunit A; PMID: 7642123 best DB hits: BLAST: swissprot:P41513; GYRA_ERWCA DNA GYRASE SUBUNIT A ----- pir:; E=1e-105 gb:AAB95117.1; (U56906) DNA gyrase [Serratia marcescens]; E=1e-105 swissprot:P48372; GYRA_PSEAE DNA GYRASE SUBUNIT A ----- pir:; E=1e-104 COG: PA3168; COG0188 DNA gyrase (topoisomerase II) A subunit; E=1e-105 PFAM: PF00521; DNA gyrase/topoisomerase IV, su; E=2.9e-225.
 
 
 0.982
gyrA-2
DNA gyrase subunit A; PMID: 2987847 best DB hits: BLAST: swissprot:P05653; GYRA_BACSU DNA GYRASE SUBUNIT A ----- pir:; E=0.0 swissprot:P48372; GYRA_PSEAE DNA GYRASE SUBUNIT A -----pir:; E=0.0 gb:AAC34892.1; (AF085683) DNA gyrase A subunit [Methylovorus sp; E=0.0 COG: BS_gyrA; COG0188 DNA gyrase (topoisomerase II) A subunit; E=0.0 PFAM: PF00521; DNA gyrase/topoisomerase IV, su; E=1.3e-246.
 
 
 0.981
pknB-5
Probable serine/threonine-protein kinase pknB; PMID: 8969512 best DB hits: BLAST: gb:AAF73695.1; (AE002226) serinethreonine-protein kinase; E=6e-30 pir:G71532; probable threoninetyrosine-specific protein kinase (EC; E=3e-29 gb:AAF73573.1; (AE002326) serinethreonine protein kinase; E=1e-28 COG: CT301_1; COG0515 Serine/threonine protein kinases; E=3e-30 PFAM: PF00069; Protein kinase domain; E=0.0026.
  
    0.775
recA
RecA protein (Recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.763
rpoC
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
  
 0.693
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
  
 0.682
dnaK
Chaperone protein HscC; PMID: 9735342 best DB hits: BLAST: swissprot:P77319; HSCC_ECOLI CHAPERONE PROTEIN HSCC (HSC62); E=1e-92 gb:AAG54984.1; AE005244_2 (AE005244) putative dnaK protein; E=3e-91 embl:CAA06391.1; (AJ005129) dnaK [Thermotoga maritima]; E=3e-88 COG: ybeW; COG0443 Molecular chaperone; E=1e-93 PFAM: PF01869; BadF/BadG/BcrA/BcrD ATPase fa; E=0.37 PF00012; Hsp70 protein; E=9.1e-147.
  
 
 
 0.679
RB5920
WD40 repeat protein; PMID: 10322433 best DB hits: BLAST: swissprot:Q00808; HET1_PODAN VEGETATIBLE INCOMPATIBILITY PROTEIN; E=3e-25 swissprot:P49695; PKWA_THECU PUTATIVE SERINETHREONINE-PROTEIN; E=5e-21 swissprot:Q9UGP9; WDR5_HUMAN WD-REPEAT PROTEIN 5 ----- embl:; E=8e-20 COG: slr0143_2; COG2319 WD40 repeat protein; E=1e-16 PFAM: PF00400; WD domain, G-beta repeat; E=0.0064.
   
 
 0.653
trpS
tryptophan-tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.
      
 0.615
ileS
Probable isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
 
  
 0.582
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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