STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ruvCCrossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (178 aa)    
Predicted Functional Partners:
ruvA
Probable holliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
  
 
 0.965
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
 
 0.934
cysS
cysteinyl-tRNA synthetase; PMID: 2014166 PMID: 1864365 best DB hits: BLAST: gb:AAK03029.1; (AE006134) CysS [Pasteurella multocida]; E=5e-91 swissprot:Q9KGF4; SYC_BACHD CYSTEINYL-TRNA SYNTHETASE; E=2e-89 swissprot:O58370; SYC_PYRHO CYSTEINYL-TRNA SYNTHETASE; E=3e-88 COG: BH0111; COG0215 Cysteinyl-tRNA synthetase; E=2e-90 PFAM: PF01406; tRNA synthetases class I (C); E=1.8e-122; Belongs to the class-I aminoacyl-tRNA synthetase family.
     
 0.863
RB4676
Hypothetical protein-transmembrane prediction.
       0.773
RB4670
Hypothetical protein-transmembrane prediction; Best DB hits: BLAST: gb:AAF82144.1; AC034256_8 (AC034256) Contains similarity to F-box; E=8e-04 ddbj:BAB21785.1; (AB051481) KIAA1694 protein [Homo sapiens]; E=0.40.
       0.610
comM
comM protein; PMID: 9457884 best DB hits: BLAST: pir:S75721; hypothetical protein slr0904 - Synechocystis sp. (strain; E=1e-117 pir:G72368; comM protein - Thermotoga maritima (strain MSB8) -----; E=1e-113 pir:C75370; Mg(2+) chelatase family protein - Deinococcus; E=1e-111 COG: slr0904; COG0606 Predicted ATPases; E=1e-118 BH3051; COG1067 Predicted ATP-dependent protease; ATPase domain; E=7e-06 MTH556; COG1239 Mg-chelatase subunit ChlI; E=5e-04 PFAM: PF01078; Magnesium chelatase, subunit; E=1.2e-10 PF01202; Shikimate kinase; E=0.29 PF01695; IstB-like ATP binding protein; E=0.57.
  
   
 0.574
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.556
recO
Probable DNA repair protein recO; Involved in DNA repair and RecF pathway recombination.
 
  
 0.544
def
Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
 
 
 
 0.468
RB5500
Conserved hypothetical protein; PMID: 9665876 best DB hits: BLAST: swissprot:O83487; Y474_TREPA HYPOTHETICAL PROTEIN TP0474 -----; E=5e-54 swissprot:Q51423; Y964_PSEAE HYPOTHETICAL PROTEIN PA0964 -----; E=2e-53 swissprot:O67517; YF75_AQUAE HYPOTHETICAL PROTEIN AQ_1575 -----; E=5e-53 COG: TP0474; COG0217 Uncharacterized ACR; E=4e-55 PFAM: PF01709; Domain of unknown function DUF28; E=8e-105.
 
  
 0.464
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.