STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (937 aa)    
Predicted Functional Partners:
eno
Enolase (2-phosphoglycerate dehydratase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
 
 0.930
pykA
Pyruvate kinase; PMID: 9387221 best DB hits: BLAST: ddbj:BAB06882.1; (AP001517) pyruvate kinase [Bacillus halodurans]; E=4e-82 swissprot:P80885; KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE; E=6e-80 swissprot:P51181; KPYK_BACLI PYRUVATE KINASE (PK) ----- pir:; E=1e-79 COG: BH3163_1; COG0469 Pyruvate kinase; E=4e-83 PFAM: PF00478; IMP dehydrogenase; Belongs to the pyruvate kinase family.
     
 0.929
pyc
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
     
 0.929
ppdK
Pyruvate,phosphate dikinase; PMID: 2176881 best DB hits: BLAST: pir:F72397; pyruvate,orthophosphate dikinase (EC 2.7.9.1) -; E=0.0 swissprot:P22983; PODK_CLOSY PYRUVATE,PHOSPHATE DIKINASE; E=0.0 pdb:1DIK; Pyruvate Phosphate Dikinase; E=0.0 COG: TM0272; COG0574 Phosphoenolpyruvate synthase; E=0.0 PA3562_3; COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI; E=2e-27 MTH1118; COG0574 Phosphoenolpyruvate synthase; E=1e-22 PFAM: PF01326; Pyruvate phosphate dikinase,; E=1.1e-167 PF00391; PEP-utilizing enzyme, mobile; E=4.1e-37 PF02896; PEP-utilizing enzyme, TIM bar; E=3e-141; Belongs [...]
     
 0.929
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
     
 0.912
RB6610
Hypothetical protein; Best DB hits: PFAM: PF00639; PPIC-type PPIASE domain; E=0.81.
     
  0.900
gltB
Glutamate synthase [NADPH] large chain; PMID: 2643092 PMID: 3326786 best DB hits: BLAST: swissprot:Q06434; GLSF_ANTSP FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE; E=0.0 swissprot:P23225; GLSF_MAIZE FERREDOXIN-DEPENDENT GLUTAMATE; E=0.0 swissprot:Q03460; GLSN_MEDSA GLUTAMATE SYNTHASE [NADH], CHLOROPLAST; E=0.0 COG: sll1502_2; COG0069 Glutamate synthetase domain 2; E=0.0 sll1502_1; COG0067 Glutamate synthetase domain 1; E=1e-118 PFAM: PF01645; Conserved region in glutamate; E=5.5e-235 PF01493; Domain of unknown function DU; E=4.2e-95.
  
  
 0.877
gltA
Citrate synthase; PMID: 2337600 PMID: 6380576 best DB hits: BLAST: gb:AAF04133.1; AF191033_1 (AF191033) citrate synthase; E=1e-152 embl:CAB66275.1; (AL136519) citrate synthase. [Streptomyces; E=1e-149 swissprot:Q10530; CISY_MYCTU CITRATE SYNTHASE 1 ----- pir:; E=1e-145 COG: Rv0896; COG0372 Citrate synthase; E=1e-146 PFAM: PF00285; Citrate synthase; E=1e-208.
     
 0.858
purU
Formyltetrahydrofolate deformylase; PMID: 7868604 best DB hits: BLAST: gb:AAG20130.1; (AE005091) formyltetrahydrofolate deformylase; E=5e-24 swissprot:Q55135; PURU_SYNY3 FORMYLTETRAHYDROFOLATE DEFORMYLASE; E=3e-17 pir:C82633; formyltetrahydrofolate deformylase XF1831 [imported] -; E=2e-15 COG: VNG1946G; COG0788 Formyltetrahydrofolate hydrolase; E=5e-25 TM1248; COG0299 Folate-dependent phosphoribosylglycinamide; E=2e-07 Rv2964; COG0788 Formyltetrahydrofolate hydrolase; E=8e-07 PFAM: PF00551; Formyl transferase; E=1.4e-10.
     
  0.800
RB4941
Hypothetical protein.
       0.718
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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