STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (219 aa)    
Predicted Functional Partners:
exoA
Exodeoxyribonuclease; PMID: 1708495 best DB hits: BLAST: swissprot:P37454; EXOA_BACSU EXODEOXYRIBONUCLEASE ----- pir:; E=7e-78 pir:F64710; exodeoxyribonuclease - Helicobacter pylori (strain; E=3e-72 pir:C71809; exodeoxyribonuclease - Helicobacter pylori (strain J99); E=2e-71 COG: BS_exoA; COG0708 Exonuclease III; E=7e-79 PFAM: PF01181; Deoxyribonuclease I (DNase I); E=0.25 PF01260; AP endonuclease family 1; E=2e-108.
 
 0.962
nqrD
Sodium-translocating NADH dehydrogenase (ubiquinone) subunit nqrD; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family.
 
    
 0.859
mutY
A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
  
  
 0.749
RB5098
Serine acetyltransferase, plasmid; PMID: 7603442 best DB hits: BLAST: swissprot:Q59967; SRPH_SYNP7 SERINE ACETYLTRANSFERASE, PLASMID; E=7e-55 ddbj:BAA82868.1; (AB023954) serine acetyltransferase [Entamoeba; E=3e-35 ddbj:BAA82870.1; (AB023956) serine acetyltransferase 2 [Entamoeba; E=8e-34 COG: BH0110; COG1045 Serine acetyltransferase; E=3e-30 BS_ykuQ; COG2171 Tetrahydrodipicolinate N-succinyltransferase; E=2e-04 wcaB; COG1045 Serine acetyltransferase; E=0.002 PFAM: PF00132; Bacterial transferase hexapeptide (f; E=0.078.
       0.701
RB5730
Conserved hypothetical protein-putative ATP-utilizing enzyme; PMID: 8905231 best DB hits: BLAST: swissprot:P73846; YH17_SYNY3 HYPOTHETICAL 30.2 KD PROTEIN SLR1717; E=1e-37 gb:AAB89691.1; (AE000995) conserved hypothetical protein; E=3e-28 pir:C72312; conserved hypothetical protein - Thermotoga maritima; E=7e-28 COG: slr1717; COG1606 ATP-utilizing enzymes of the PP-loop superfamily; E=1e-38 PFAM: PF00764; Arginosuccinate synthase; E=0.042.
 
    0.666
RB2794
Deoxyribonuclease gamma [precursor]; PMID: 9665719 best DB hits: BLAST: gb:AAC64266.1; (AF059612) deoxyribonuclease gamma [Xenopus; E=1e-19 gb:AAB00496.1; (L40823) DNL1L gene product [Homo sapiens]; E=5e-17 gb:AAB17022.1; (U06846) XIB [Homo sapiens]; E=7e-17 PFAM: PF01181; Deoxyribonuclease I (DNase I); E=1.3e-10.
  
 0.644
dnl1
PMID: 9469931 best DB hits: BLAST: swissprot:P00639; DRN1_BOVIN DEOXYRIBONUCLEASE I PRECURSOR (DNASE; E=6e-11 pdb:3DNI; Deoxyribonuclease I (Dnase I) (E.C.3.1.21.1) -----; E=6e-11 pdb:1ATN; D Chain D, Deoxyribonuclease I Complex With Actin; E=9e-11 PFAM: PF01181; Deoxyribonuclease I (DNase I); E=0.053.
  
 0.644
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.615
mutM
Probable formamidopyrimidine-DNA glycosylase; PMID: 7704272 best DB hits: BLAST: swissprot:O53191; YO64_MYCTU PUTATIVE DNA GLYCOSYLASE RV2464C; E=6e-55 embl:CAC10002.1; (AL442143) putative DNA repair hydrolase; E=6e-46 swissprot:P95744; FPG_SYNEN FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; E=1e-14 COG: Rv2464c; COG0266 Formamidopyrimidine-DNA glycosylase; E=2e-55 PFAM: PF01149; Formamidopyrimidine-DNA glycos; E=4.3e-40.
   
  
 0.607
mutM-2
formamidopyrimidine-DNA glycosylase; PMID: 96102858 best DB hits: BLAST: swissprot:P55044; FPG_NEIMB FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; E=2e-29 swissprot:P95744; FPG_SYNEN FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; E=6e-29 prf:2204218A; formamidopyrimidine-DNA glycosylase [Neisseria; E=7e-28 COG: NMB1295; COG0266 Formamidopyrimidine-DNA glycosylase; E=2e-30 PFAM: PF01149; Formamidopyrimidine-DNA glycos; E=6.4e-14; Belongs to the FPG family.
   
  
 0.607
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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