STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cyaA-2Adenylate cyclase 1; PMID: 9523018 best DB hits: BLAST: pir:C71320; probable adenylate cyclase - syphilis spirochete -----; E=8e-40 pir:F70563; probable transmembrane protein - Mycobacterium; E=2e-35 embl:CAA18817.1; (AL023093) putative membrane protein; E=4e-35 COG: TP0485; COG2114 Adenylate cyclase, family 3 (some proteins contain; E=8e-41 slr1991_2; COG2114 Adenylate cyclase, family 3 (some proteins; E=9e-14 PA3217; COG2114 Adenylate cyclase, family 3 (some proteins contain; E=4e-12 PFAM: PF00672; HAMP domain; E=8.7e-11 PF00211; Adenylate and Guanylate cyclase; E=7e-26. (589 aa)    
Predicted Functional Partners:
RB641
Sensory histidine protein kinase; Best DB hits: BLAST: pir:G82753; two-component system, sensor protein XF0853 [imported] -; E=2e-41 gb:AAA98756.1; (L29642) sensor kinase [Pseudomonas fluorescens]; E=8e-39 pir:A82300; sensory box sensor histidine kinaseresponse regulator; E=4e-34 COG: XF0853; COG0642 Sensory transduction histidine kinases; E=2e-42 sll0779_1; COG2202 PAS/PAC domain; E=1e-23 VCA0736_1; COG0642 Sensory transduction histidine kinases; E=1e-23 PFAM: PF00785; PAC motif; E=8.5e-08 PF00989; PAS domain; E=0.013 PF00785; PAC motif; E=0.1.
   
 
 0.937
cya
Probable adenylate cyclase; PMID: 1970565 best DB hits: BLAST: swissprot:P40137; CYAA_STIAU ADENYLATE CYCLASE 1 (ATP; E=9e-11 swissprot:P19485; CYA1_RHIME ADENYLATE CYCLASE 1 (ATP; E=2e-10 pir:C71320; probable adenylate cyclase - syphilis spirochete -----; E=3e-10 COG: TP0485; COG2114 Adenylate cyclase, family 3 (some proteins contain; E=2e-11 PFAM: PF00498; FHA domain; E=0.61 PF00211; Adenylate and Guanylate cyclase; E=1.1e-07.
  
  
 
0.930
cyaA-3
Adenylate cyclase 1; PMID: 9523018 PMID: 8418825 best DB hits: BLAST: swissprot:P40137; CYAA_STIAU ADENYLATE CYCLASE 1 (ATP; E=8e-24 pir:S74929; adenylate cyclase (EC 4.6.1.1) - Synechocystis sp; E=1e-23 ddbj:BAA13997.1; (D89622) adenylate cyclase [Anabaena sp.]; E=4e-23 COG: sll0646; COG2114 Adenylate cyclase, family 3 (some proteins contain; E=1e-24 slr1991_2; COG2114 Adenylate cyclase, family 3 (some proteins; E=3e-08 Rv1625c; COG2114 Adenylate cyclase, family 3 (some proteins contain; E=4e-08 PFAM: PF00211; Adenylate and Guanylate cyclase; E=2.7e-39.
  
  
 
0.929
RB6328
Adenylyl cyclase related protein; PMID: 9371463 best DB hits: BLAST: pir:F69084; conserved hypothetical protein MTH1629 -; E=1e-20 pir:C71193; hypothetical protein PH1819 - Pyrococcus horikoshii; E=8e-18 swissprot:Q57692; Y240_METJA HYPOTHETICAL PROTEIN MJ0240 -----; E=1e-17 COG: MTH1629; COG1437 Adenylate cyclase, class 2 (thermophilic); E=1e-21 PFAM: PF01928; Adenylate cyclase; E=2.9e-45.
     
 0.907
pykA
Pyruvate kinase; PMID: 9387221 best DB hits: BLAST: ddbj:BAB06882.1; (AP001517) pyruvate kinase [Bacillus halodurans]; E=4e-82 swissprot:P80885; KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE; E=6e-80 swissprot:P51181; KPYK_BACLI PYRUVATE KINASE (PK) ----- pir:; E=1e-79 COG: BH3163_1; COG0469 Pyruvate kinase; E=4e-83 PFAM: PF00478; IMP dehydrogenase; Belongs to the pyruvate kinase family.
     
 0.906
ndk
Nucleoside diphosphate kinase (NDK); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.902
RB5445
Similar to 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; PMID: 8260624 best DB hits: BLAST: embl:CAB08432.1; (Z95151) Icc [Mycobacterium leprae]; E=0.062 pir:S44374; phosphoglycerate mutase (EC 5.4.2.1) - castor bean; E=0.20 swissprot:Q42908; PMGI_MESCR 2,3-BISPHOSPHOGLYCERATE-INDEPENDENT; E=0.22.
     
 0.901
RB2978
Probable MutT-family protein; PMID: 8843436 best DB hits: BLAST: embl:CAC16440.1; (AL450165) putative MutT-family protein; E=2e-05 swissprot:P56380; AP4A_MOUSE BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE; E=5e-05 pir:F75532; MutTnudix family protein - Deinococcus radiodurans; E=3e-04 COG: DR0329; COG0494 NTP pyrophosphohydrolases including oxidative damage; E=3e-05 DR0004; COG0494 NTP pyrophosphohydrolases including oxidative; E=4e-05 DR0550; COG0494 NTP pyrophosphohydrolases including oxidative damage; E=1e-04 PFAM: PF00293; MutT-like domain; E=4.8e-17.
     
 0.900
ribA
Riboflavin biosynthesis protein RibA; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family.
    
 0.829
folE
GTP cyclohydrolase I; PMID: 1551827 PMID: 95352066 best DB hits: BLAST: swissprot:P19465; GCH1_BACSU GTP CYCLOHYDROLASE I (GTP-CH-I); E=1e-59 ddbj:BAB05365.1; (AP001512) GTP cyclohydrolase I [Bacillus; E=1e-57 swissprot:O06273; GCH1_MYCTU GTP CYCLOHYDROLASE I (GTP-CH-I); E=4e-53 COG: BS_mtrA; COG0302 GTP cyclohydrolase I; E=1e-60 PFAM: PF01227; GTP cyclohydrolase I; E=2.3e-110.
    
  0.810
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.