STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (366 aa)    
Predicted Functional Partners:
ruvA
Probable holliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
 
 0.992
ruvC
Crossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
 
 
 0.934
queA
S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
 
  
 0.871
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.824
pcrA
ATP-dependent DNA helicase; PMID: 8419285 best DB hits: BLAST: gb:AAK05218.1; AE006344_7 (AE006344) ATP-dependent helicase PcrA; E=1e-131 swissprot:Q53727; PCRA_STAAU ATP-DEPENDENT DNA HELICASE PCRA; E=1e-127 swissprot:Q9S3Q0; PCRA_LEUCI ATP-DEPENDENT DNA HELICASE PCRA; E=1e-127 COG: BS_yerF; COG0210 Superfamily I DNA and RNA helicases; E=1e-127 PFAM: PF00580; UvrD/REP helicase; E=2.4e-177.
 
  
 0.763
pcrA-2
ATP-dependent DNA helicase; PMID: 10192928 PMID: 3029683 best DB hits: BLAST: ddbj:BAB04367.1; (AP001509) ATP-dependent DNA helicase [Bacillus; E=1e-121 swissprot:Q53727; PCRA_STAAU ATP-DEPENDENT DNA HELICASE PCRA; E=1e-115 swissprot:P56255; PCRA_BACST ATP-DEPENDENT DNA HELICASE PCRA; E=1e-114 COG: BH0648; COG0210 Superfamily I DNA and RNA helicases; E=1e-122 PFAM: PF00580; UvrD/REP helicase; E=5.6e-173.
 
  
 0.762
ligA
DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
  
   
 0.706
gidA
Glucose inhibited division protein A (GIDA); NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family.
  
  
 0.614
coaD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
  
 0.583
RB6962
Conserved hypothetical protein-putative transcriptional regulator; Best DB hits: BLAST: pir:T36872; hypothetical protein SCI51.09c - Streptomyces coelicolor; E=4e-08 swissprot:P35155; YPUH_BACSU HYPOTHETICAL 22.0 KD PROTEIN IN; E=3e-07 pir:D71320; conserved hypothetical protein TP0458 - syphilis; E=5e-06 COG: BS_ypuH; COG1386 Predicted transcriptional regulator containing the; E=2e-08.
       0.573
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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