STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pknB-8Probable serine/threonine-protein kinase pknB; PMID: 1835671 best DB hits: BLAST: swissprot:P54744; PKNB_MYCLE PUTATIVE SERINETHREONINE-PROTEIN; E=2e-35 pir:T36501; probable serinethreonine protein kinase - Streptomyces; E=2e-34 embl:CAB94054.1; (AL358672) putative serinethreonine-protein; E=4e-34 COG: Rv0014c_1; COG0515 Serine/threonine protein kinases; E=2e-33 PFAM: PF00069; Protein kinase domain; E=3e-52 PF00191; Annexin; E=0.78. (780 aa)    
Predicted Functional Partners:
RB3245
Protein phosphatase 1; PMID: 11298281 best DB hits: BLAST: gb:AAF81068.1; AF223364_3 (AF223364) protein phosphatase 1; E=3e-27 pir:E71538; hypothetical protein CT259 - Chlamydia trachomatis; E=5e-26 embl:CAA10712.1; (AJ132604) pppL protein [Lactococcus lactis]; E=2e-25 COG: CT259; COG0631 Protein serine/threonine phosphatases; E=4e-27 PFAM: PF00481; Protein phosphatase 2C; E=1.2e-09.
  
   0.802
Pph1
Probable protein phosphatase 1; PMID: 11298281 best DB hits: BLAST: gb:AAF81068.1; AF223364_3 (AF223364) protein phosphatase 1; E=9e-32 pir:E71538; hypothetical protein CT259 - Chlamydia trachomatis; E=4e-28 pir:H75265; conserved hypothetical protein - Deinococcus radiodurans; E=5e-28 COG: CT259; COG0631 Protein serine/threonine phosphatases; E=4e-29 PFAM: PF00481; Protein phosphatase 2C; E=4.9e-09.
  
   0.802
RB10367
Best DB hits: BLAST: pir:C70986; probable serinethreonine protein kinase (EC 2.7.1.-) -; E=1e-17 embl:CAB66178.1; (AL136500) probable serinethreonine protein; E=1e-15 swissprot:Q10697; PKNJ_MYCTU PROBABLE SERINETHREONINE-PROTEIN; E=6e-15 COG: Rv1746; COG0515 Serine/threonine protein kinases; E=1e-18 PFAM: PF00069; Protein kinase domain; E=3.8e-28.
  
     0.775
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
      
 0.544
RB8325
Hypothetical protein.
   
   0.529
RB8328
CMP-binding protein; PMID: 97158661 best DB hits: BLAST: gb:AAB68787.1; (U97022) orf; similar to the Staphylococcus aureus; E=6e-35 gb:AAK06020.1; AE006422_9 (AE006422) HYPOTHETICAL PROTEIN; E=2e-29 ddbj:BAB04894.1; (AP001511) CMP-binding protein [Bacillus; E=1e-28 PFAM: PF01336; OB-fold nucleic acid binding domain; E=1.4e-05 PF01966; HD domain; E=1.1e-10.
       0.525
queC
Probable transcription regulator; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
       0.525
pkn2-2
Putative serine/threonine-protein kinase; PMID: 7774814 best DB hits: BLAST: embl:CAB94054.1; (AL358672) putative serinethreonine-protein; E=9e-43 swissprot:P54736; PKN2_MYXXA SERINETHREONINE-PROTEIN KINASE PKN2; E=4e-39 swissprot:Q10697; PKNJ_MYCTU PROBABLE SERINETHREONINE-PROTEIN; E=2e-38 COG: Rv2088; COG0515 Serine/threonine protein kinases; E=2e-39 PFAM: PF00069; Protein kinase domain; E=1.6e-54.
  
  
0.488
RB10333
Protein kinase homolog; Best DB hits: BLAST: pir:T42076; protein kinase homolog - Streptomyces coelicolor -----; E=5e-18 pir:T42077; protein kinase homolog - Streptomyces coelicolor -----; E=1e-16 pir:T35491; probable serinethreonine-specific protein kinase pkaF -; E=1e-16 COG: Rv0014c_1; COG0515 Serine/threonine protein kinases; E=3e-15 PFAM: PF00069; Protein kinase domain; E=3.2e-06.
  
   
0.480
RB1789
PMID: 10484179 best DB hits: BLAST: ddbj:BAB05496.1; (AP001513) BH1777~unknown conserved protein; E=1e-04 ddbj:BAA14001.1; (D89626) adenylate cyclase [Anabaena sp.]; E=0.001 pir:B70700; hypothetical protein Rv0020c - Mycobacterium; E=0.003 COG: BH1777_1; COG1716 FHA-domain-containing proteins; E=5e-05 PFAM: PF00498; FHA domain; E=4.6e-18.
  
 
 
 0.478
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.