STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (426 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.992
hemL
PMID: 7763385 PMID: 1672867 best DB hits: BLAST: pir:E81978; probable glutamate-1-semialdehyde 2,1-aminomutase (EC; E=1e-116 swissprot:Q40147; GSA_LYCES GLUTAMATE-1-SEMIALDEHYDE; E=1e-115 swissprot:Q06741; GSA_XANCH GLUTAMATE-1-SEMIALDEHYDE; E=1e-115 COG: BS_hemL; COG0001 Glutamate-1-semialdehyde aminotransferase; E=1e-116 PFAM: PF00202; Aminotransferase class-III; E=1.8e-125.
 
 0.985
hemD
PMID: 7665501 best DB hits: BLAST: gb:AAK00606.1; AF221100_3 (AF221100) uroporphyrinogen III; E=1e-89 swissprot:Q59294; HEM4_CLOJO PORPHYRIN BIOSYNTHESIS PROTEIN HEMD; E=1e-64 gb:AAC18588.1; (AF064061) uroporphyrinogen-III; E=3e-63 COG: NMB1156_2; COG0007 Uroporphyrinogen-III methylase; E=2e-44 sll0166_2; COG1587 Uroporphyrinogen-III synthase; E=7e-30 PFAM: PF00590; Tetrapyrrole (Corrin/Porphyrin); E=1.2e-63 PF02602; Uroporphyrinogen-III synthase H; E=7.1e-43.
 
  
 0.933
gluQ
glutamyl-tRNA synthetase-related protein; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
     
 0.906
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
     
 0.906
RB1856
Delta-aminolevulinic acid dehydratase; PMID: 8226669 best DB hits: BLAST: ddbj:BAA35069.1; (AB015492) porphobilinogen synthase; E=1e-114 swissprot:P45622; HEM2_BRAJA DELTA-AMINOLEVULINIC ACID DEHYDRATASE; E=1e-108 swissprot:Q59643; HEM2_PSEAE DELTA-AMINOLEVULINIC ACID DEHYDRATASE; E=1e-105 COG: PA5243; COG0113 Delta-aminolevulinic acid dehydratase; E=1e-106 PFAM: PF00490; Delta-aminolevulinic acid dehydratas; E=1.8e-183; Belongs to the ALAD family.
 
  
 0.830
RB9844
Hypothetical protein-putative transmembrane protein.
       0.806
uroD
Uroporphyrinogen III synthase, uroporhyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.790
RB9849
Best DB hits: BLAST: pir:T34929; hypothetical protein SC3F9.07 SC3F9.07 - Streptomyces; E=3e-04.
       0.741
comE
PMID: 7968523 best DB hits: BLAST: pir:B75346; probable competence protein ComECRec2 - Deinococcus; E=2e-19 ddbj:BAA12454.1; (D84432) ComEC [Bacillus subtilis] -----; E=3e-19 swissprot:P39695; CME3_BACSU COME OPERON PROTEIN 3 ----- pir:; E=1e-18 COG: DR1854_2; COG2333 Predicted hydrolases of metallo-beta-lactamase; E=3e-16 BH1335_1; COG0658 Predicted multitransmembrane, metal-binding; E=5e-13 PA2984_2; COG2333 Predicted hydrolases of metallo-beta-lactamase; E=5e-09 PFAM: PF00753; Metallo-beta-lactamase superfamil; E=1.5e-07.
 
     0.717
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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