STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (330 aa)    
Predicted Functional Partners:
gltA
Citrate synthase; Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle. Loss in activity results in sporulation defect (By similarity).
  
 0.982
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.973
pckA
Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
  
 
 0.931
DR_2583
Malate oxidoreductase; Similar to SP:P45868 PID:853772 GB:AL009126 percent identity: 65.68; identified by sequence similarity; putative.
  
 0.927
DR_A0276
Malate oxidoreductase; Similar to GB:AL009126 percent identity: 67.66; identified by sequence similarity; putative.
  
 0.927
DR_1155
Malate synthase, putative; Similar to SP:P08997 GB:X12431 PID:396349 PID:40887 GB:U00096 percent identity: 49.74; identified by sequence similarity; putative.
   
 0.921
DR_A0277
Malate synthase; Similar to SP:P28344 PID:2702 percent identity: 71.79; identified by sequence similarity; putative; Belongs to the malate synthase family.
   
 0.921
DR_0623
Aspartate aminotransferase; Similar to PID:1255699 percent identity: 75.92; identified by sequence similarity; putative.
  
 0.919
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family.
   
 
 0.912
DR_0183
Glutamate synthase, large subunit; Similar to PID:1339950 percent identity: 71.96; identified by sequence similarity; putative.
  
 
 0.886
Your Current Organism:
Deinococcus radiodurans
NCBI taxonomy Id: 243230
Other names: D. radiodurans R1, Deinococcus radiodurans R1, Deinococcus radiodurans str. R1
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