node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DR_0588 | DR_1691 | DR_0588 | DR_1691 | ATP-dependent Clp protease, ATP-binding subunit ClpA; Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 72.69; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Heat shock protein-related protein; Similar to GB:D12635 GB:M80186 GB:U83670 SP:P31673 PID:1815662 percent identity: 56.18; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | 0.629 |
DR_0588 | clpP | DR_0588 | DR_1972 | ATP-dependent Clp protease, ATP-binding subunit ClpA; Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 72.69; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.812 |
DR_0588 | dnaJ | DR_0588 | DR_1424 | ATP-dependent Clp protease, ATP-binding subunit ClpA; Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 72.69; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.750 |
DR_0588 | dnaK | DR_0588 | DR_0129 | ATP-dependent Clp protease, ATP-binding subunit ClpA; Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 72.69; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.875 |
DR_0588 | groL | DR_0588 | DR_0607 | ATP-dependent Clp protease, ATP-binding subunit ClpA; Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 72.69; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | groEL protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.592 |
DR_0588 | grpE | DR_0588 | DR_0128 | ATP-dependent Clp protease, ATP-binding subunit ClpA; Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 72.69; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | grpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.681 |
DR_0588 | lon | DR_0588 | DR_0349 | ATP-dependent Clp protease, ATP-binding subunit ClpA; Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 72.69; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | ATP-dependent protease LA; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.572 |
DR_1117 | DR_1691 | DR_1117 | DR_1691 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Similar to SP:P31541 percent identity: 71.25; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Heat shock protein-related protein; Similar to GB:D12635 GB:M80186 GB:U83670 SP:P31673 PID:1815662 percent identity: 56.18; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | 0.629 |
DR_1117 | clpP | DR_1117 | DR_1972 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Similar to SP:P31541 percent identity: 71.25; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.836 |
DR_1117 | dnaJ | DR_1117 | DR_1424 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Similar to SP:P31541 percent identity: 71.25; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.692 |
DR_1117 | dnaK | DR_1117 | DR_0129 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Similar to SP:P31541 percent identity: 71.25; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.865 |
DR_1117 | groL | DR_1117 | DR_0607 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Similar to SP:P31541 percent identity: 71.25; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | groEL protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.561 |
DR_1117 | grpE | DR_1117 | DR_0128 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Similar to SP:P31541 percent identity: 71.25; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | grpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.681 |
DR_1117 | lon | DR_1117 | DR_0349 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Similar to SP:P31541 percent identity: 71.25; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | ATP-dependent protease LA; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.523 |
DR_1691 | DR_0588 | DR_1691 | DR_0588 | Heat shock protein-related protein; Similar to GB:D12635 GB:M80186 GB:U83670 SP:P31673 PID:1815662 percent identity: 56.18; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease, ATP-binding subunit ClpA; Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 72.69; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | 0.629 |
DR_1691 | DR_1117 | DR_1691 | DR_1117 | Heat shock protein-related protein; Similar to GB:D12635 GB:M80186 GB:U83670 SP:P31673 PID:1815662 percent identity: 56.18; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease, ATP-binding subunit ClpC; Similar to SP:P31541 percent identity: 71.25; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | 0.629 |
DR_1691 | clpB | DR_1691 | DR_1046 | Heat shock protein-related protein; Similar to GB:D12635 GB:M80186 GB:U83670 SP:P31673 PID:1815662 percent identity: 56.18; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | 0.629 |
DR_1691 | dnaJ | DR_1691 | DR_1424 | Heat shock protein-related protein; Similar to GB:D12635 GB:M80186 GB:U83670 SP:P31673 PID:1815662 percent identity: 56.18; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.454 |
DR_1691 | dnaK | DR_1691 | DR_0129 | Heat shock protein-related protein; Similar to GB:D12635 GB:M80186 GB:U83670 SP:P31673 PID:1815662 percent identity: 56.18; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.604 |
DR_1691 | grpE | DR_1691 | DR_0128 | Heat shock protein-related protein; Similar to GB:D12635 GB:M80186 GB:U83670 SP:P31673 PID:1815662 percent identity: 56.18; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | grpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.511 |