STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gltACitrate synthase; Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle. Loss in activity results in sporulation defect (By similarity). (411 aa)    
Predicted Functional Partners:
acn
Aconitate hydratase; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis- aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein.
 
 0.997
DR_1540
Isocitrate dehydrogenase; Similar to PID:1752679 percent identity: 83.37; identified by sequence similarity; putative.
 
 
 0.989
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.982
acsA
acetyl-CoA synthase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.973
DR_0032
2-oxo acid dehydrogenase, E2 component; Similar to GB:X53560 SP:P11961 PID:580909 percent identity: 61.98; identified by sequence similarity; putative.
  
 0.970
DR_0256
Pyruvate dehydrogenase complex, dihydrolipoamide acetyltransferase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.970
DR_0460
acetyl-CoA synthase; Similar to PID:1001216 PID:1001254 percent identity: 62.90; identified by sequence similarity; putative.
  
 0.965
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.955
DR_1155
Malate synthase, putative; Similar to SP:P08997 GB:X12431 PID:396349 PID:40887 GB:U00096 percent identity: 49.74; identified by sequence similarity; putative.
  
 0.953
DR_A0277
Malate synthase; Similar to SP:P28344 PID:2702 percent identity: 71.79; identified by sequence similarity; putative; Belongs to the malate synthase family.
  
 0.953
Your Current Organism:
Deinococcus radiodurans
NCBI taxonomy Id: 243230
Other names: D. radiodurans R1, Deinococcus radiodurans R1, Deinococcus radiodurans str. R1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.