STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DR_1626Branched-chain amino acid aminotransferase; Similar to GB:L42023 PID:1007062 PID:1221316 PID:1205436 SP:P54689 percent identity: 82.60; identified by sequence similarity; putative; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (358 aa)    
Predicted Functional Partners:
ilvD
Dihydroxy-acid dehydratase; Similar to GB:L42023 SP:P44851 PID:1005684 PID:1220826 PID:1204985 percent identity: 83.08; identified by sequence similarity; putative; Belongs to the IlvD/Edd family.
  
 0.969
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 0.959
DR_0030
2-oxo acid dehydrogenase, E1 component, beta subunit; Similar to GB:M97391 SP:P37941 PID:142612 PID:1303943 GB:AL009126 percent identity: 71.16; identified by sequence similarity; putative.
  
 0.927
DR_0158
Branched-chain amino acid dehydrogenase; Similar to GB:X79068 PID:483472 percent identity: 60.65; identified by sequence similarity; putative; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.915
DR_0029
2-oxo acid dehydrogenase, E1 component, alpha subunit; Similar to SP:P11960 PID:203121 percent identity: 55.26; identified by sequence similarity; putative.
  
 
 0.914
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
    
 0.913
ilvA
Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.877
DR_1278
Homoserine dehydrogenase; Similar to SP:P08499 GB:Y00476 PID:297383 PID:40503 percent identity: 56.69; identified by sequence similarity; putative.
  
 
 0.870
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.840
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate.
  
 0.834
Your Current Organism:
Deinococcus radiodurans
NCBI taxonomy Id: 243230
Other names: D. radiodurans R1, Deinococcus radiodurans R1, Deinococcus radiodurans str. R1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.