node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DR_0055 | lexA | DR_0055 | DR_A0344 | Repressor protein, putative; Similar to PID:567887 percent identity: 54.84; identified by sequence similarity; putative. | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.538 |
DR_0055 | recA | DR_0055 | DR_2340 | Repressor protein, putative; Similar to PID:567887 percent identity: 54.84; identified by sequence similarity; putative. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). Probably involved in base excision repair ; Belongs to the RecA family. | 0.412 |
DR_A0345 | lexA | DR_A0345 | DR_A0344 | Hypothetical protein; Identified by Glimmer2; putative. | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.709 |
DR_A0345 | pprA | DR_A0345 | DR_A0346 | Hypothetical protein; Identified by Glimmer2; putative. | DNA damage repair protein; dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end- joining (NHEJ) pathway for the repair of radiation-induced DNA double- strands breaks. Cannot bind [...] | 0.463 |
argR | lexA | DR_0742 | DR_A0344 | Arginine repressor/activator; Regulates arginine biosynthesis genes. | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.616 |
argR | recN | DR_0742 | DR_1477 | Arginine repressor/activator; Regulates arginine biosynthesis genes. | DNA repair protein; May be involved in recombinational repair of damaged DNA. Belongs to the RecN family. | 0.404 |
cinA | lexA | DR_2338 | DR_A0344 | cinA protein; Similar to PID:2251087 percent identity: 100.00; identified by sequence similarity; putative; Belongs to the CinA family. | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.594 |
cinA | recA | DR_2338 | DR_2340 | cinA protein; Similar to PID:2251087 percent identity: 100.00; identified by sequence similarity; putative; Belongs to the CinA family. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). Probably involved in base excision repair ; Belongs to the RecA family. | 0.973 |
cinA | recN | DR_2338 | DR_1477 | cinA protein; Similar to PID:2251087 percent identity: 100.00; identified by sequence similarity; putative; Belongs to the CinA family. | DNA repair protein; May be involved in recombinational repair of damaged DNA. Belongs to the RecN family. | 0.446 |
cinA | recX | DR_2338 | DR_1310 | cinA protein; Similar to PID:2251087 percent identity: 100.00; identified by sequence similarity; putative; Belongs to the CinA family. | Regulatory protein RecX, putative; Modulates RecA activity; Belongs to the RecX family. | 0.669 |
irrE | lexA | DR_0167 | DR_A0344 | Hypothetical protein; Plays a central regulatory role in DNA repair and protection pathways in response to radiation stress. Acts as a site-specific metalloprotease that cleaves and inactivates the repressor protein DdrO, resulting in induced expression of genes required for DNA repair and cell survival after exposure to radiation (By similarity). Regulates the expression of dozens of proteins from different pathways, including the important DNA repair proteins RecA and PprA. Binds to the promoters of recA and pprA. | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.627 |
irrE | pprA | DR_0167 | DR_A0346 | Hypothetical protein; Plays a central regulatory role in DNA repair and protection pathways in response to radiation stress. Acts as a site-specific metalloprotease that cleaves and inactivates the repressor protein DdrO, resulting in induced expression of genes required for DNA repair and cell survival after exposure to radiation (By similarity). Regulates the expression of dozens of proteins from different pathways, including the important DNA repair proteins RecA and PprA. Binds to the promoters of recA and pprA. | DNA damage repair protein; dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end- joining (NHEJ) pathway for the repair of radiation-induced DNA double- strands breaks. Cannot bind [...] | 0.790 |
irrE | recA | DR_0167 | DR_2340 | Hypothetical protein; Plays a central regulatory role in DNA repair and protection pathways in response to radiation stress. Acts as a site-specific metalloprotease that cleaves and inactivates the repressor protein DdrO, resulting in induced expression of genes required for DNA repair and cell survival after exposure to radiation (By similarity). Regulates the expression of dozens of proteins from different pathways, including the important DNA repair proteins RecA and PprA. Binds to the promoters of recA and pprA. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). Probably involved in base excision repair ; Belongs to the RecA family. | 0.808 |
lexA | DR_0055 | DR_A0344 | DR_0055 | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Repressor protein, putative; Similar to PID:567887 percent identity: 54.84; identified by sequence similarity; putative. | 0.538 |
lexA | DR_A0345 | DR_A0344 | DR_A0345 | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Hypothetical protein; Identified by Glimmer2; putative. | 0.709 |
lexA | argR | DR_A0344 | DR_0742 | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Arginine repressor/activator; Regulates arginine biosynthesis genes. | 0.616 |
lexA | cinA | DR_A0344 | DR_2338 | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | cinA protein; Similar to PID:2251087 percent identity: 100.00; identified by sequence similarity; putative; Belongs to the CinA family. | 0.594 |
lexA | irrE | DR_A0344 | DR_0167 | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Hypothetical protein; Plays a central regulatory role in DNA repair and protection pathways in response to radiation stress. Acts as a site-specific metalloprotease that cleaves and inactivates the repressor protein DdrO, resulting in induced expression of genes required for DNA repair and cell survival after exposure to radiation (By similarity). Regulates the expression of dozens of proteins from different pathways, including the important DNA repair proteins RecA and PprA. Binds to the promoters of recA and pprA. | 0.627 |
lexA | pprA | DR_A0344 | DR_A0346 | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA damage repair protein; dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end- joining (NHEJ) pathway for the repair of radiation-induced DNA double- strands breaks. Cannot bind [...] | 0.665 |
lexA | recA | DR_A0344 | DR_2340 | lexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). Probably involved in base excision repair ; Belongs to the RecA family. | 0.985 |