node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GSU0523 | hisA | GSU0523 | GSU3096 | Pyridoxal-5'-phosphate-dependent chorismate-binding enzyme, putative. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.515 |
GSU0523 | trpA | GSU0523 | GSU2371 | Pyridoxal-5'-phosphate-dependent chorismate-binding enzyme, putative. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.960 |
GSU0523 | trpB1 | GSU0523 | GSU2375 | Pyridoxal-5'-phosphate-dependent chorismate-binding enzyme, putative. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.957 |
GSU0523 | trpC | GSU0523 | GSU2380 | Pyridoxal-5'-phosphate-dependent chorismate-binding enzyme, putative. | Indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. | 0.993 |
GSU0523 | trpD | GSU0523 | GSU2381 | Pyridoxal-5'-phosphate-dependent chorismate-binding enzyme, putative. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.997 |
GSU0523 | trpE | GSU0523 | GSU2383 | Pyridoxal-5'-phosphate-dependent chorismate-binding enzyme, putative. | Anthranilate synthase, catalytic subunit; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] | 0.885 |
GSU0523 | trpF | GSU0523 | GSU2378 | Pyridoxal-5'-phosphate-dependent chorismate-binding enzyme, putative. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.954 |
GSU0523 | trpG | GSU0523 | GSU2382 | Pyridoxal-5'-phosphate-dependent chorismate-binding enzyme, putative. | Anthranilate synthase, glutamine amidotransferase subunit. | 0.999 |
hisA | GSU0523 | GSU3096 | GSU0523 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Pyridoxal-5'-phosphate-dependent chorismate-binding enzyme, putative. | 0.515 |
hisA | hisH | GSU3096 | GSU3097 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | trpB1 | GSU3096 | GSU2375 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.735 |
hisA | trpC | GSU3096 | GSU2380 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. | 0.758 |
hisA | trpD | GSU3096 | GSU2381 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.638 |
hisA | trpF | GSU3096 | GSU2378 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.865 |
hisH | hisA | GSU3097 | GSU3096 | Imidazoleglycerol-phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.999 |
hisH | trpE | GSU3097 | GSU2383 | Imidazoleglycerol-phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Anthranilate synthase, catalytic subunit; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] | 0.690 |
hisH | trpF | GSU3097 | GSU2378 | Imidazoleglycerol-phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.876 |
hisH | trpG | GSU3097 | GSU2382 | Imidazoleglycerol-phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Anthranilate synthase, glutamine amidotransferase subunit. | 0.868 |
trpA | GSU0523 | GSU2371 | GSU0523 | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | Pyridoxal-5'-phosphate-dependent chorismate-binding enzyme, putative. | 0.960 |
trpA | trpB1 | GSU2371 | GSU2375 | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.999 |