node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MG_011 | MG_012 | MG_011 | MG_012 | Conserved hypothetical protein; MG011 has a below trusted cutoff similarity to alpha-L-glutamate ligases, RimK family (TIGR00768). The adjacent gene, MG012, is a strong hit to that family; identified by similarity to EGAD:56791. | alpha-L-glutamate ligases, RimK family, putative; Identified by similarity to EGAD:56788; match to protein family HMM PF02222; match to protein family HMM TIGR00768; Belongs to the RimK family. | 0.945 |
MG_011 | folD | MG_011 | MG_013 | Conserved hypothetical protein; MG011 has a below trusted cutoff similarity to alpha-L-glutamate ligases, RimK family (TIGR00768). The adjacent gene, MG012, is a strong hit to that family; identified by similarity to EGAD:56791. | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.776 |
MG_012 | MG_011 | MG_012 | MG_011 | alpha-L-glutamate ligases, RimK family, putative; Identified by similarity to EGAD:56788; match to protein family HMM PF02222; match to protein family HMM TIGR00768; Belongs to the RimK family. | Conserved hypothetical protein; MG011 has a below trusted cutoff similarity to alpha-L-glutamate ligases, RimK family (TIGR00768). The adjacent gene, MG012, is a strong hit to that family; identified by similarity to EGAD:56791. | 0.945 |
MG_012 | folD | MG_012 | MG_013 | alpha-L-glutamate ligases, RimK family, putative; Identified by similarity to EGAD:56788; match to protein family HMM PF02222; match to protein family HMM TIGR00768; Belongs to the RimK family. | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.776 |
MG_245 | MG_246 | MG_245 | MG_246 | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | Identified by similarity to PDB:1T71_A; match to protein family HMM PF00149; match to protein family HMM TIGR00282. | 0.803 |
MG_245 | folD | MG_245 | MG_013 | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.964 |
MG_245 | glyA | MG_245 | MG_394 | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.518 |
MG_245 | pepP | MG_245 | MG_324 | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | Metallopeptidase family M24 aminopeptidase; Identified by similarity to GB:AAN81374.1; match to protein family HMM PF00557; Belongs to the peptidase M24B family. | 0.744 |
MG_245 | tsaD | MG_245 | MG_046 | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | Metalloendopeptidase, putative, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.647 |
MG_246 | MG_245 | MG_246 | MG_245 | Identified by similarity to PDB:1T71_A; match to protein family HMM PF00149; match to protein family HMM TIGR00282. | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | 0.803 |
MG_246 | folD | MG_246 | MG_013 | Identified by similarity to PDB:1T71_A; match to protein family HMM PF00149; match to protein family HMM TIGR00282. | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.760 |
fmt | folD | MG_365 | MG_013 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.983 |
fmt | glyA | MG_365 | MG_394 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.932 |
fmt | thyA | MG_365 | MG_227 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.497 |
folD | MG_011 | MG_013 | MG_011 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Conserved hypothetical protein; MG011 has a below trusted cutoff similarity to alpha-L-glutamate ligases, RimK family (TIGR00768). The adjacent gene, MG012, is a strong hit to that family; identified by similarity to EGAD:56791. | 0.776 |
folD | MG_012 | MG_013 | MG_012 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | alpha-L-glutamate ligases, RimK family, putative; Identified by similarity to EGAD:56788; match to protein family HMM PF02222; match to protein family HMM TIGR00768; Belongs to the RimK family. | 0.776 |
folD | MG_245 | MG_013 | MG_245 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | 0.964 |
folD | MG_246 | MG_013 | MG_246 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Identified by similarity to PDB:1T71_A; match to protein family HMM PF00149; match to protein family HMM TIGR00282. | 0.760 |
folD | fmt | MG_013 | MG_365 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.983 |
folD | glyA | MG_013 | MG_394 | Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |