STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MG_385Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols. MG293 and MG385 comprise a parrologous gene family. Both can be disrupted when grown on SP-4 media(Glass et al. 2005); identified by similarity to SP:P37965; match to protein family HMM PF03009. (236 aa)    
Predicted Functional Partners:
MG_293
Glycerophosphoryl diester phosphodiesterase family protein; MG293 and MG385 comprise a parrologous gene family. Both can be disrupted (Glass et al. 2005); identified by similarity to EGAD:56951; match to protein family HMM PF03009; To glycerophosphoryl diester phosphodiesterases (EC 3.1.4.46).
     
 
0.900
p200
P200 protein; Could be an accessory structural component in cytadherence.
       0.774
pstA
Phosphate ABC transporter, permease protein PstA; Could be part of a binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
  
  
 0.520
MG_524
Conserved hypothetical protein; MG384.1 has 3 transmembrane regions. old_locus_tag=MG384.1; identified by similarity to EGAD:57035.
  
    0.491
obg
GTPase1 Obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
       0.467
nadE
NH(3)-dependent NAD+ synthetase, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
       0.462
MG_390
ABC transporter, ATP-binding/permease protein; MG390 has 4 transmembrane regions, plus and ATP binding domain, and a peptidase domain. There is no predicted substrate binding protein or other ABC transporter component in the vicinity; identified by similarity to GB:AAA03343.1; match to protein family HMM PF00005; match to protein family HMM PF03412.
  
    0.441
ybeY
Expressed protein of unknown function; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA; Belongs to the endoribonuclease YbeY family.
       0.429
era
GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
       0.419
ptsG
PTS system, glucose-specific IIABC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport.
     
 0.410
Your Current Organism:
Mycoplasma genitalium
NCBI taxonomy Id: 243273
Other names: M. genitalium G37, Mycoplasma genitalium ATCC 33530, Mycoplasma genitalium G37, Mycoplasma genitalium str. G37, Mycoplasma genitalium strain G37
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