node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MG_459 | ftsH | MG_459 | MG_457 | Conserved hypothetical protein; MG459 may encode a 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; however M. genitalium does not synthesize isoprenyl pyrophosphate via deoxyxylulose; identified by similarity to EGAD:56901; match to protein family HMM PF02542. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.481 |
MG_459 | hpt | MG_459 | MG_458 | Conserved hypothetical protein; MG459 may encode a 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; however M. genitalium does not synthesize isoprenyl pyrophosphate via deoxyxylulose; identified by similarity to EGAD:56901; match to protein family HMM PF02542. | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:Q02522; match to protein family HMM PF00156; match to protein family HMM TIGR01203. | 0.792 |
MG_459 | ldh | MG_459 | MG_460 | Conserved hypothetical protein; MG459 may encode a 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; however M. genitalium does not synthesize isoprenyl pyrophosphate via deoxyxylulose; identified by similarity to EGAD:56901; match to protein family HMM PF02542. | L-lactate dehydrogenase/malate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. | 0.528 |
apt | deoD | MG_276 | MG_049 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase; Identified by similarity to SP:P09743; match to protein family HMM PF01048; match to protein family HMM TIGR00107; Belongs to the PNP/UDP phosphorylase family. | 0.946 |
apt | gmk | MG_276 | MG_107 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.981 |
apt | hpt | MG_276 | MG_458 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:Q02522; match to protein family HMM PF00156; match to protein family HMM TIGR01203. | 0.983 |
apt | upp | MG_276 | MG_030 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.497 |
deoD | apt | MG_049 | MG_276 | Purine nucleoside phosphorylase; Identified by similarity to SP:P09743; match to protein family HMM PF01048; match to protein family HMM TIGR00107; Belongs to the PNP/UDP phosphorylase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.946 |
deoD | hpt | MG_049 | MG_458 | Purine nucleoside phosphorylase; Identified by similarity to SP:P09743; match to protein family HMM PF01048; match to protein family HMM TIGR00107; Belongs to the PNP/UDP phosphorylase family. | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:Q02522; match to protein family HMM PF00156; match to protein family HMM TIGR01203. | 0.907 |
deoD | tdk | MG_049 | MG_034 | Purine nucleoside phosphorylase; Identified by similarity to SP:P09743; match to protein family HMM PF01048; match to protein family HMM TIGR00107; Belongs to the PNP/UDP phosphorylase family. | Thymidine kinase; Identified by similarity to SP:Q03221; match to protein family HMM PF00265. | 0.972 |
deoD | upp | MG_049 | MG_030 | Purine nucleoside phosphorylase; Identified by similarity to SP:P09743; match to protein family HMM PF01048; match to protein family HMM TIGR00107; Belongs to the PNP/UDP phosphorylase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.929 |
ftsH | MG_459 | MG_457 | MG_459 | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Conserved hypothetical protein; MG459 may encode a 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; however M. genitalium does not synthesize isoprenyl pyrophosphate via deoxyxylulose; identified by similarity to EGAD:56901; match to protein family HMM PF02542. | 0.481 |
ftsH | hpt | MG_457 | MG_458 | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:Q02522; match to protein family HMM PF00156; match to protein family HMM TIGR01203. | 0.787 |
ftsH | ldh | MG_457 | MG_460 | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | L-lactate dehydrogenase/malate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. | 0.418 |
ftsH | tilS | MG_457 | MG_084 | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.550 |
gap | gmk | MG_301 | MG_107 | Glyceraldehyde-3-phosphate dehydrogenase, type I; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.423 |
gap | hpt | MG_301 | MG_458 | Glyceraldehyde-3-phosphate dehydrogenase, type I; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:Q02522; match to protein family HMM PF00156; match to protein family HMM TIGR01203. | 0.479 |
gap | ldh | MG_301 | MG_460 | Glyceraldehyde-3-phosphate dehydrogenase, type I; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | L-lactate dehydrogenase/malate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. | 0.835 |
gmk | apt | MG_107 | MG_276 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.981 |
gmk | gap | MG_107 | MG_301 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Glyceraldehyde-3-phosphate dehydrogenase, type I; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. | 0.423 |