STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rad50Probable DNA double-strand break repair Rad50 ATPase; Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity) (852 aa)    
Predicted Functional Partners:
sbcD
Nuclease SbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
 
 
 0.999
lon
Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
  
  
 0.889
Tmari_1646
Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology
       0.886
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
 
  
 0.859
Tmari_1641
ATPase YjeE, predicted to have essential role in cell wall biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology
       0.853
Tmari_1643
Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology
       0.845
TM_1639
Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PyrK family
  
    0.812
Tmari_1649
Glutamate synthase [NADPH] small chain; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: Protein Homology
       0.806
Tmari_1647
ABC transporter, ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology
       0.806
Tmari_1747
5-3 nuclease; Derived by automated computational analysis using gene prediction method: Protein Homology
     
 0.737
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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