STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TDE_2271HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (194 aa)    
Predicted Functional Partners:
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
 
 0.978
guaB
Inosine-5'-monophosphate dehydrogenase; Identified by similarity to SP:P50097; match to protein family HMM PF00478; match to protein family HMM PF00571.
  
 0.925
murI
Glutamate racemase, putative; Provides the (R)-glutamate required for cell wall biosynthesis.
    0.846
TDE_2272
Hypothetical protein; Identified by Glimmer2; putative.
       0.836
TDE_1578
Phosphoesterase, putative; Identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040.
  
  
 0.790
uppS
Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
 
    0.639
TDE_2546
Membrane protein, putative; Identified by similarity to GP:20517171; match to protein family HMM PF02588.
 
    0.607
TDE_0713
Transcription antitermination protein, NusG family; Identified by match to protein family HMM PF00467.
   
    0.586
nusG
Transcription antitermination protein NusG; Participates in transcription elongation, termination and antitermination.
   
    0.586
TDE_2273
Hypothetical protein; Identified by Glimmer2; putative.
       0.567
Your Current Organism:
Treponema denticola
NCBI taxonomy Id: 243275
Other names: T. denticola ATCC 35405, Treponema denticola ATCC 35405, Treponema denticola str. ATCC 35405
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