node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TDE_0046 | TDE_0296 | TDE_0046 | TDE_0296 | Identified by match to protein family HMM PF04961. | Formiminotransferase, putative; Identified by match to protein family HMM PF02971. | 0.998 |
TDE_0046 | fhs | TDE_0046 | TDE_0019 | Identified by match to protein family HMM PF04961. | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.945 |
TDE_0046 | folD | TDE_0046 | TDE_0013 | Identified by match to protein family HMM PF04961. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.945 |
TDE_0046 | gcvT | TDE_0046 | TDE_1627 | Identified by match to protein family HMM PF04961. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.934 |
TDE_0046 | purH | TDE_0046 | TDE_1896 | Identified by match to protein family HMM PF04961. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P26978; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.905 |
TDE_0046 | purN | TDE_0046 | TDE_1897 | Identified by match to protein family HMM PF04961. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.909 |
TDE_0296 | TDE_0046 | TDE_0296 | TDE_0046 | Formiminotransferase, putative; Identified by match to protein family HMM PF02971. | Identified by match to protein family HMM PF04961. | 0.998 |
TDE_0296 | fhs | TDE_0296 | TDE_0019 | Formiminotransferase, putative; Identified by match to protein family HMM PF02971. | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.915 |
TDE_0296 | folD | TDE_0296 | TDE_0013 | Formiminotransferase, putative; Identified by match to protein family HMM PF02971. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.911 |
TDE_0296 | gcvT | TDE_0296 | TDE_1627 | Formiminotransferase, putative; Identified by match to protein family HMM PF02971. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.902 |
TDE_0296 | glyA | TDE_0296 | TDE_2668 | Formiminotransferase, putative; Identified by match to protein family HMM PF02971. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
TDE_0296 | purH | TDE_0296 | TDE_1896 | Formiminotransferase, putative; Identified by match to protein family HMM PF02971. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P26978; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.900 |
TDE_0296 | purN | TDE_0296 | TDE_1897 | Formiminotransferase, putative; Identified by match to protein family HMM PF02971. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.900 |
TDE_0296 | thyX | TDE_0296 | TDE_0311 | Formiminotransferase, putative; Identified by match to protein family HMM PF02971. | Thymidylate synthase-complementing family protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.901 |
fhs | TDE_0046 | TDE_0019 | TDE_0046 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Identified by match to protein family HMM PF04961. | 0.945 |
fhs | TDE_0296 | TDE_0019 | TDE_0296 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Formiminotransferase, putative; Identified by match to protein family HMM PF02971. | 0.915 |
fhs | folD | TDE_0019 | TDE_0013 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.998 |
fhs | gcvT | TDE_0019 | TDE_1627 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.958 |
fhs | glyA | TDE_0019 | TDE_2668 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.978 |
fhs | purC | TDE_0019 | TDE_0686 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:Q59925; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by similarity to OMNI:CC3242; match to protein family HMM PF01259; Belongs to the SAICAR synthetase family. | 0.872 |