STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pepACytosol aminopeptidase family protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (476 aa)    
Predicted Functional Partners:
TDE_2228
Aminoacyl-histidine dipeptidase, putative; Identified by similarity to SP:P15288; match to protein family HMM PF01546; match to protein family HMM TIGR01893.
   
 
 0.917
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.834
TDE_1669
Hemolysin; Identified by similarity to GP:9955069.
  
 
  0.808
TDE_2410
Hemolysin; Identified by similarity to GP:1019859; match to protein family HMM PF00155.
  
 
  0.808
TDE_0301
Tetracenomycin polyketide synthesis O-methyltransferase TcmP, putative; Identified by similarity to SP:P39887.
       0.565
htpG
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity.
   
    0.559
TDE_1482
Identified by match to protein family HMM PF00557.
  
 
 0.467
groEL
Chaperonin, 60 kDa; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.454
TDE_0492
Sensor histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF02518.
  
  
 0.444
TDE_0302
Conserved hypothetical protein; Identified by match to protein family HMM PF04221.
       0.425
Your Current Organism:
Treponema denticola
NCBI taxonomy Id: 243275
Other names: T. denticola ATCC 35405, Treponema denticola ATCC 35405, Treponema denticola str. ATCC 35405
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