STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (338 aa)    
Predicted Functional Partners:
arcC
Carbamate kinase; Identified by match to protein family HMM PF00696; match to protein family HMM TIGR00746; Belongs to the carbamate kinase family.
 
 
 0.997
arcA
Arginine deiminase; Identified by similarity to SP:P16962; match to protein family HMM PF02274; match to protein family HMM TIGR01078.
 
 
 0.996
pyrBI
PyrBI protein; Identified by match to protein family HMM PF00185; match to protein family HMM PF01948; match to protein family HMM PF02729; match to protein family HMM PF02748; match to protein family HMM TIGR00670; In the N-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
    
 0.886
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.624
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.610
TDE_0815
Membrane protein, putative; Identified by match to protein family HMM PF03606.
 
  
 0.577
TDE_0982
Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding; Identified by match to protein family HMM PF00970; match to protein family HMM PF01180; match to protein family HMM TIGR01037.
  
  
 0.572
TDE_0926
Phosphonate ABC transporter, permease protein, putative; Identified by similarity to SP:P16683; match to protein family HMM PF00528.
       0.559
TDE_0927
Phosphonate ABC transporter, permease protein, putative; Identified by match to protein family HMM PF00528.
       0.559
phnC
Phosphonate ABC transporter, ATP-binding protein, putative; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
       0.559
Your Current Organism:
Treponema denticola
NCBI taxonomy Id: 243275
Other names: T. denticola ATCC 35405, Treponema denticola ATCC 35405, Treponema denticola str. ATCC 35405
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