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megL protein (Treponema denticola) - STRING interaction network
"megL" - L-methionine gamma-lyase in Treponema denticola
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
megLL-methionine gamma-lyase; Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia; methanethiol (methyl mercaptan) is considered to be one of the main causes of bad oral smell associated with periodontitis and may also play a role in the pathogenicity of T.denticola. Also displays homocysteine desulfhydrase activity, degrading homocysteine to produce hydrogen sulfide, 2-oxobutanoate and ammonia; Belongs to the trans-sulfuration enzymes family. L- methionine gamma-lyase subfamily (401 aa)    
Predicted Functional Partners:
metK
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (389 aa)
     
  0.966
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (793 aa)
   
 
  0.918
trxB
Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM TIGR01292; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family (317 aa)
     
 
  0.909
msrA
Peptide methionine sulfoxide reductase MsrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (317 aa)
   
 
  0.857
TDE_2198
Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1201 aa)
              0.844
TDE_0016
ATPase, AAA family; Identified by match to protein family HMM PF00004 (441 aa)
   
   
  0.838
TDE_2201
Uncharacterized protein; Identified by Glimmer2; putative (43 aa)
              0.727
TDE_0665
Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1186 aa)
         
  0.662
TDE_1482
Identified by match to protein family HMM PF00557 (585 aa)
   
 
  0.623
TDE_2199
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis (224 aa)
              0.598
Your Current Organism:
Treponema denticola
NCBI taxonomy Id: 243275
Other names: T. denticola ATCC 35405, Treponema denticola, Treponema denticola ATCC 35405, Treponema denticola ATCC35405, Treponema denticola str. ATCC 35405
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