STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
potDSpermidine/putrescine ABC transporter, periplasmic binding protein (potD); Similar to GB:M64519 SP:P23861 PID:147329 GB:U00096 PID:1651550 percent identity: 31.38; identified by sequence similarity; putative. (348 aa)    
Predicted Functional Partners:
potA
Spermidine/putrescine ABC transporter, ATP-binding protein (potA); Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
 
 
 0.999
potB
Spermidine/putrescine ABC transporter, permease protein (potB); Similar to GB:AE000782 percent identity: 29.22; identified by sequence similarity; putative.
 
 
 0.999
potC
Spermidine/putrescine ABC transporter, permease protein (potC); Similar to GB:L42023 SP:P45169 PID:1007355 PID:1221477 PID:1205581 percent identity: 40.16; identified by sequence similarity; putative.
 
 0.999
TP_0142
Thiamine ABC transporter, ATP-binding protein, putative; Similar to GB:L42023 SP:P45171 PID:1007359 PID:1221479 PID:1205583 percent identity: 36.19; identified by sequence similarity; putative.
  
 
 0.942
TP_0804
Sugar ABC transporter, ATP-binding protein (ugpC); Similar to SP:P10907 GB:U00039 PID:43249 PID:912455 GB:U00096 percent identity: 47.77; identified by sequence similarity; putative; Belongs to the ABC transporter superfamily.
    
 0.744
ugpA
Sugar ABC transporter, permease protein (y4oQ); Similar to SP:P55602 PID:2182561 percent identity: 35.94; identified by sequence similarity; putative.
    
  0.666
sbcC
Exonuclease (sbcC); SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity); Belongs to the SMC family. SbcC subfamily.
    
  0.666
topA
DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]
     
 0.640
ybeY
Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
       0.497
TP_0957
Tp33 protein; Similar to GB:X61228 PID:48229 percent identity: 92.86; identified by sequence similarity; putative.
      
 0.455
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.