STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dacAConserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (273 aa)    
Predicted Functional Partners:
TP_0827
Predicted coding region TP0827; Hypothetical protein; identified by Glimmer; putative.
 
  
 0.985
acpS
Holo-acyl-carrier protein synthase (acpS); Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.
       0.837
TP_0829
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 43.38; identified by sequence similarity; putative.
       0.837
truA
Pseudouridylate synthase (hisT); Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
       0.837
dxs
Transketolase B (tktB); Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
       0.798
TP_0825
Predicted coding region TP0825; Hypothetical protein; identified by Glimmer; putative.
       0.773
TP_0413
Phosphoglucomutase; Similar to GB:AE000783 percent identity: 35.60; identified by sequence similarity; putative.
   
 
 0.756
TP_0642
Phosphomannomutase (manB); Similar to GB:M34393 SP:P18159 PID:142994 PID:2226139 GB:AL009126 percent identity: 41.55; identified by sequence similarity; putative.
   
 
 0.756
TP_0288
Spore coat polysaccharide biosynthesis protein (spsF); Similar to GB:X73124 SP:P39626 PID:413992 GB:AL009126 percent identity: 31.88; identified by sequence similarity; putative.
  
 
   0.469
dnaZX2
DNA polymerase III, subunits gamma and tau (dnaH); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. Belongs to the DnaX/STICHEL family.
   
   0.461
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.