STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_2497Conserved hypothetical protein; Identified by Glimmer2; putative. (417 aa)    
Predicted Functional Partners:
VC_A0924
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
  
 0.784
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
     
 0.770
VC_A0785
GGDEF family protein; Similar to PID:1651932; identified by sequence similarity; putative.
 
 0.747
VC_1367
GGDEF family protein; Similar to PID:633121; identified by sequence similarity; putative.
 
 
 0.742
VC_A0557
GGDEF family protein; Similar to GB:U00096 SP:P75908 PID:1787262; identified by sequence similarity; putative.
 
 
 0.742
VC_1067
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
 
 0.726
VC_A0530
Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative.
   
   0.675
VC_A0895
Chemotactic transducer-related protein; Similar to PID:1652854; identified by sequence similarity; putative.
  
  
 0.667
vdcA
GGDEF family protein; Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic- di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation, and reduced motility and virulence.
 
 
 0.643
VC_1156
Sensor histidine kinase; Similar to GP:2655263; identified by sequence similarity; putative.
  
 
 0.628
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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