STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)    
Predicted Functional Partners:
sdhA
Succinate dehydrogenase, flavoprotein subunit; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG1053; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.993
frdA
Fumarate reductase flavoprotein subunit; Identified by sequence similarity; putative; ORF located using Blastx/COG1053.
 
 0.990
fumA
Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.986
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.975
maeB
NADP-dependent malate dehydrogenase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0281.
  
 
 0.974
sdhC
Succinate dehydrogenase cytochrome b-556 subunit; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2009.
  
 
 0.969
sdhB
Succinate dehydrogenase iron-sulfur protein; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 0.967
frdB
Fumarate reductase, subunit B; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG0479.
  
 0.967
aceB
Malate synthase A; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2225; Belongs to the malate synthase family.
    
 0.928
sdhD
Succinate dehydrogenase, hydrophobic subunit; Identified by sequence similarity; putative; ORF located using GeneMark/Blastx/COG2142.
  
 
 0.926
Your Current Organism:
Chromobacterium violaceum
NCBI taxonomy Id: 243365
Other names: C. violaceum ATCC 12472, Chromobacterium violaceum ATCC 12472, Chromobacterium violaceum ATCC12472, Chromobacterium violaceum str. ATCC 12472
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