node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CV_3746 | apt | CV_3746 | CV_3772 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG0518. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.949 |
CV_3746 | gmk | CV_3746 | CV_3770 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG0518. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.921 |
CV_3746 | guaA | CV_3746 | CV_3465 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG0518. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.920 |
CV_3746 | guaC | CV_3746 | CV_2922 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG0518. | Probable GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.973 |
CV_3746 | hpT | CV_3746 | CV_3900 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG0518. | Hypoxanthine phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0634. | 0.930 |
apt | CV_3746 | CV_3772 | CV_3746 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG0518. | 0.949 |
apt | gmk | CV_3772 | CV_3770 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.976 |
apt | guaA | CV_3772 | CV_3465 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.992 |
apt | guaC | CV_3772 | CV_2922 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Probable GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.940 |
apt | hpT | CV_3772 | CV_3900 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0634. | 0.940 |
apt | ndk | CV_3772 | CV_3542 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.405 |
apt | rpoZ | CV_3772 | CV_3769 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.480 |
apt | spoT | CV_3772 | CV_3768 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.430 |
gmk | CV_3746 | CV_3770 | CV_3746 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/COG0518. | 0.921 |
gmk | apt | CV_3770 | CV_3772 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.976 |
gmk | guaA | CV_3770 | CV_3465 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.970 |
gmk | guaC | CV_3770 | CV_2922 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Probable GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.934 |
gmk | hpT | CV_3770 | CV_3900 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine phosphoribosyltransferase; Identified by sequence similarity; putative; ORF located using Glimmer/GeneMark/Blastx/COG0634. | 0.935 |
gmk | ndk | CV_3770 | CV_3542 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.930 |
gmk | nrdA | CV_3770 | CV_2287 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribonucleoside-diphosphate reductase system; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.922 |