node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHY_0493 | CHY_0494 | CHY_0493 | CHY_0494 | Radical SAM domain protein; Identified by similarity to GB:AAL81282.1; match to protein family HMM PF04055. | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | 0.989 |
CHY_0493 | gcvH | CHY_0493 | CHY_0490 | Radical SAM domain protein; Identified by similarity to GB:AAL81282.1; match to protein family HMM PF04055. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.864 |
CHY_0493 | gcvPA | CHY_0493 | CHY_0491 | Radical SAM domain protein; Identified by similarity to GB:AAL81282.1; match to protein family HMM PF04055. | Glycine dehydrogenase (decarboxylating), subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.868 |
CHY_0493 | gcvPB | CHY_0493 | CHY_0492 | Radical SAM domain protein; Identified by similarity to GB:AAL81282.1; match to protein family HMM PF04055. | Glycine dehydrogenase (decarboxylating), subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.869 |
CHY_0493 | gcvT | CHY_0493 | CHY_0489 | Radical SAM domain protein; Identified by similarity to GB:AAL81282.1; match to protein family HMM PF04055. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.874 |
CHY_0493 | lipM | CHY_0493 | CHY_0495 | Radical SAM domain protein; Identified by similarity to GB:AAL81282.1; match to protein family HMM PF04055. | Biotin/lipoate A/B protein ligase family protein; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. | 0.958 |
CHY_0494 | CHY_0493 | CHY_0494 | CHY_0493 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Radical SAM domain protein; Identified by similarity to GB:AAL81282.1; match to protein family HMM PF04055. | 0.989 |
CHY_0494 | gcvH | CHY_0494 | CHY_0490 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.855 |
CHY_0494 | gcvPA | CHY_0494 | CHY_0491 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine dehydrogenase (decarboxylating), subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.864 |
CHY_0494 | gcvPB | CHY_0494 | CHY_0492 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine dehydrogenase (decarboxylating), subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.864 |
CHY_0494 | gcvT | CHY_0494 | CHY_0489 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.882 |
CHY_0494 | lipM | CHY_0494 | CHY_0495 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Biotin/lipoate A/B protein ligase family protein; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. | 0.954 |
acpP | gcvH | CHY_1446 | CHY_0490 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.905 |
acpP | lpdA | CHY_1446 | CHY_0713 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. | Alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00890; match to protein family HMM PF01134; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.618 |
folD | gcvH | CHY_1878 | CHY_0490 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.877 |
folD | gcvPB | CHY_1878 | CHY_0492 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine dehydrogenase (decarboxylating), subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.658 |
folD | gcvT | CHY_1878 | CHY_0489 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.967 |
folD | glyA | CHY_1878 | CHY_2557 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.984 |
folD | lpdA | CHY_1878 | CHY_0713 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00890; match to protein family HMM PF01134; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.766 |
gcvH | CHY_0493 | CHY_0490 | CHY_0493 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Radical SAM domain protein; Identified by similarity to GB:AAL81282.1; match to protein family HMM PF04055. | 0.864 |