STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (276 aa)    
Predicted Functional Partners:
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 0.999
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
  
  
 0.984
birA
BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.932
CHY_2378
Conserved hypothetical protein; Identified by similarity to GB:AAO81619.1; match to protein family HMM PF01210; match to protein family HMM PF03807.
 
   
 0.928
ilvD
Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family.
     
 0.924
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
    
 0.915
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by similarity to SP:P29252; match to protein family HMM PF01288; match to protein family HMM TIGR01498.
 
  
 0.907
nadC
Nicotinate-nucleotide pyrophosphorylase; Identified by match to protein family HMM PF01729; match to protein family HMM PF02749; match to protein family HMM TIGR00078; Belongs to the NadC/ModD family.
      0.906
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.754
coaX
Puatative transcriptional activator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family.
     
 0.745
Your Current Organism:
Carboxydothermus hydrogenoformans
NCBI taxonomy Id: 246194
Other names: C. hydrogenoformans Z-2901, Carboxydothermus hydrogenoformans Z-2901, Carboxydothermus hydrogenoformans str. Z-2901
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