STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
grdAGlycine reductase, selenoprotein A; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination (By similarity). (156 aa)    
Predicted Functional Partners:
grdB
Glycine reductase, selenoprotein B; In the first step of glycine reductase, the substrate is bound to component PB via a Schiff base intermediate. Then the PB- activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination (By similarity).
 
  
 0.990
grdE
Glycine reductase proprotein GrdE; Identified by similarity to GP:2274933.
 
   
 0.973
grdC
Glycine reductase complex, protein C; Identified by similarity to SP:P54935.
 
   
 0.925
grdD
Glycine reductase complex, protein D; Identified by similarity to GP:2708734; match to protein family HMM PF02504.
 
   
 0.921
grdX
grdX protein; Identified by similarity to GP:11065684.
 
   
 0.920
CHY_2390
Putative thioredoxin; Identified by match to protein family HMM PF00085; Belongs to the thioredoxin family.
 
   
 0.905
trxB2
Thioredoxin-disulfide reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF07992; match to protein family HMM TIGR01292.
 
   
 0.897
CHY_0560
Thioredoxin/thioredoxin-disulfide reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00085; match to protein family HMM PF01134; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292.
     
 0.816
trxB1
Thioredoxin-disulfide reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292.
     
 0.754
trx1
Thioredoxin; Identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; Belongs to the thioredoxin family.
     
 0.730
Your Current Organism:
Carboxydothermus hydrogenoformans
NCBI taxonomy Id: 246194
Other names: C. hydrogenoformans Z-2901, Carboxydothermus hydrogenoformans Z-2901, Carboxydothermus hydrogenoformans str. Z-2901
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.