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grdA protein (Carboxydothermus hydrogenoformans) - STRING interaction network
"grdA" - Glycine/sarcosine/betaine reductase complex component A in Carboxydothermus hydrogenoformans
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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grdAGlycine/sarcosine/betaine reductase complex component A; In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination (By sim [...] (156 aa)    
Predicted Functional Partners:
grdB
Glycine reductase complex component B subunit gamma; In the first step of glycine reductase, the substrate is bound to component PB via a Schiff base intermediate. Then the PB- activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination (By similarity) (435 aa)
 
   
  0.993
grdE
Glycine reductase proprotein GrdE; Identified by similarity to GP-2274933 (428 aa)
 
     
  0.984
grdC
Glycine reductase complex, protein C; Identified by similarity to SP-P54935 (509 aa)
 
     
  0.925
grdD
Glycine reductase complex, protein D; Identified by similarity to GP-2708734; match to protein family HMM PF02504 (381 aa)
 
     
  0.922
grdX
GrdX protein; Identified by similarity to GP-11065684 (131 aa)
 
     
  0.916
trxB2
Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF07992; match to protein family HMM TIGR01292; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family (307 aa)
 
     
  0.911
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family (398 aa)
         
    0.900
CHY_0560
Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF00085; match to protein family HMM PF01134; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family (426 aa)
         
  0.847
CHY_2390
Thioredoxin; Identified by match to protein family HMM PF00085; Belongs to the thioredoxin family (109 aa)
 
     
  0.825
trxB1
Thioredoxin reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family (305 aa)
         
  0.751
Your Current Organism:
Carboxydothermus hydrogenoformans
NCBI taxonomy Id: 246194
Other names: C. hydrogenoformans Z-2901, Carboxydothermus hydrogenoformans, Carboxydothermus hydrogenoformans Z-2901, Carboxydothermus hydrogenoformans str. Z-2901
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